Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0065804
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dc.titleGenetic Loci for Retinal Arteriolar Microcirculation
dc.contributor.authorSim, X.
dc.contributor.authorJensen, R.A.
dc.contributor.authorIkram, M.K.
dc.contributor.authorCotch, M.F.
dc.contributor.authorLi, X.
dc.contributor.authorMacGregor, S.
dc.contributor.authorXie, J.
dc.contributor.authorSmith, A.V.
dc.contributor.authorBoerwinkle, E.
dc.contributor.authorMitchell, P.
dc.contributor.authorKlein, R.
dc.contributor.authorKlein, B.E.K.
dc.contributor.authorGlazer, N.L.
dc.contributor.authorLumley, T.
dc.contributor.authorMcKnight, B.
dc.contributor.authorPsaty, B.M.
dc.contributor.authorde Jong, P.T.V.M.
dc.contributor.authorHofman, A.
dc.contributor.authorRivadeneira, F.
dc.contributor.authorUitterlinden, A.G.
dc.contributor.authorvan Duijn, C.M.
dc.contributor.authorAspelund, T.
dc.contributor.authorEiriksdottir, G.
dc.contributor.authorHarris, T.B.
dc.contributor.authorJonasson, F.
dc.contributor.authorLauner, L.J.
dc.contributor.authorAttia, J.
dc.contributor.authorBaird, P.N.
dc.contributor.authorHarrap, S.
dc.contributor.authorHolliday, E.G.
dc.contributor.authorInouye, M.
dc.contributor.authorRochtchina, E.
dc.contributor.authorScott, R.J.
dc.contributor.authorViswanathan, A.
dc.contributor.authorLi, G.
dc.contributor.authorSmith, N.L.
dc.contributor.authorWiggins, K.L.
dc.contributor.authorKuo, J.Z.
dc.contributor.authorTaylor, K.D.
dc.contributor.authorHewitt, A.W.
dc.contributor.authorMartin, N.G.
dc.contributor.authorMontgomery, G.W.
dc.contributor.authorSun, C.
dc.contributor.authorYoung, T.L.
dc.contributor.authorMackey, D.A.
dc.contributor.authorvan Zuydam, N.R.
dc.contributor.authorDoney, A.S.F.
dc.contributor.authorPalmer, C.N.A.
dc.contributor.authorMorris, A.D.
dc.contributor.authorRotter, J.I.
dc.contributor.authorTai, E.S.
dc.contributor.authorGudnason, V.
dc.contributor.authorVingerling, J.R.
dc.contributor.authorSiscovick, D.S.
dc.contributor.authorWang, J.J.
dc.contributor.authorWong, T.Y.
dc.date.accessioned2014-11-26T07:44:55Z
dc.date.available2014-11-26T07:44:55Z
dc.date.issued2013-06-12
dc.identifier.citationSim, X., Jensen, R.A., Ikram, M.K., Cotch, M.F., Li, X., MacGregor, S., Xie, J., Smith, A.V., Boerwinkle, E., Mitchell, P., Klein, R., Klein, B.E.K., Glazer, N.L., Lumley, T., McKnight, B., Psaty, B.M., de Jong, P.T.V.M., Hofman, A., Rivadeneira, F., Uitterlinden, A.G., van Duijn, C.M., Aspelund, T., Eiriksdottir, G., Harris, T.B., Jonasson, F., Launer, L.J., Attia, J., Baird, P.N., Harrap, S., Holliday, E.G., Inouye, M., Rochtchina, E., Scott, R.J., Viswanathan, A., Li, G., Smith, N.L., Wiggins, K.L., Kuo, J.Z., Taylor, K.D., Hewitt, A.W., Martin, N.G., Montgomery, G.W., Sun, C., Young, T.L., Mackey, D.A., van Zuydam, N.R., Doney, A.S.F., Palmer, C.N.A., Morris, A.D., Rotter, J.I., Tai, E.S., Gudnason, V., Vingerling, J.R., Siscovick, D.S., Wang, J.J., Wong, T.Y. (2013-06-12). Genetic Loci for Retinal Arteriolar Microcirculation. PLoS ONE 8 (6) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0065804
dc.identifier.issn19326203
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/109362
dc.description.abstractNarrow arterioles in the retina have been shown to predict hypertension as well as other vascular diseases, likely through an increase in the peripheral resistance of the microcirculatory flow. In this study, we performed a genome-wide association study in 18,722 unrelated individuals of European ancestry from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium and the Blue Mountain Eye Study, to identify genetic determinants associated with variations in retinal arteriolar caliber. Retinal vascular calibers were measured on digitized retinal photographs using a standardized protocol. One variant (rs2194025 on chromosome 5q14 near the myocyte enhancer factor 2C MEF2C gene) was associated with retinal arteriolar caliber in the meta-analysis of the discovery cohorts at genome-wide significance of P-value
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1371/journal.pone.0065804
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentOPHTHALMOLOGY
dc.description.doi10.1371/journal.pone.0065804
dc.description.sourcetitlePLoS ONE
dc.description.volume8
dc.description.issue6
dc.description.page-
dc.identifier.isiut000320322400057
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