Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pntd.0001426
Title: Economic impact of dengue illness and the cost-effectiveness of future vaccination programs in singapore
Authors: Carrasco, L.R. 
Lee, L.K.
Lee, V.J. 
Ooi, E.E.
Shepard, D.S.
Thein, T.L.
Gan, V.
Cook, A.R. 
Lye, D.
Ng, L.C.
Leo, Y.S.
Issue Date: Dec-2011
Citation: Carrasco, L.R., Lee, L.K., Lee, V.J., Ooi, E.E., Shepard, D.S., Thein, T.L., Gan, V., Cook, A.R., Lye, D., Ng, L.C., Leo, Y.S. (2011-12). Economic impact of dengue illness and the cost-effectiveness of future vaccination programs in singapore. PLoS Neglected Tropical Diseases 5 (12) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pntd.0001426
Abstract: Background: Dengue illness causes 50-100 million infections worldwide and threatens 2.5 billion people in the tropical and subtropical regions. Little is known about the disease burden and economic impact of dengue in higher resourced countries or the cost-effectiveness of potential dengue vaccines in such settings. Methods and Findings: We estimate the direct and indirect costs of dengue from hospitalized and ambulatory cases in Singapore. We consider inter alia the impacts of dengue on the economy using the human-capital and the friction cost methods. Disease burden was estimated using disability-adjusted life years (DALYs) and the cost-effectiveness of a potential vaccine program was evaluated. The average economic impact of dengue illness in Singapore from 2000 to 2009 in constant 2010 US$ ranged between $0.85 billion and $1.15 billion, of which control costs constitute 42%-59%. Using empirically derived disability weights, we estimated an annual average disease burden of 9-14 DALYs per 100 000 habitants, making it comparable to diseases such as hepatitis B or syphilis. The proportion of symptomatic dengue cases detected by the national surveillance system was estimated to be low, and to decrease with age. Under population projections by the United Nations, the price per dose threshold for which vaccines stop being more cost-effective than the current vector control program ranged from $50 for mass vaccination requiring 3 doses and only conferring 10 years of immunity to $300 for vaccination requiring 2 doses and conferring lifetime immunity. The thresholds for these vaccine programs to not be cost-effective for Singapore were $100 and $500 per dose respectively. Conclusions: Dengue illness presents a serious economic and disease burden in Singapore. Dengue vaccines are expected to be cost-effective if reasonably low prices are adopted and will help to reduce the economic and disease burden of dengue in Singapore substantially. © 2011 Carrasco et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Source Title: PLoS Neglected Tropical Diseases
URI: http://scholarbank.nus.edu.sg/handle/10635/109313
ISSN: 19352727
DOI: 10.1371/journal.pntd.0001426
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
2011_Economic_Impact_Dengue_Illness_Cost.pdf260.82 kBAdobe PDF

OPEN

PublishedView/Download

SCOPUSTM   
Citations

70
checked on Sep 13, 2019

WEB OF SCIENCETM
Citations

61
checked on Sep 13, 2019

Page view(s)

559
checked on Sep 20, 2019

Download(s)

142
checked on Sep 20, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.