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|Title:||Early experience with 68Ga-DOTATATE preparation||Authors:||Saw, M.M.||Issue Date:||2013||Citation:||Saw, M.M. (2013). Early experience with 68Ga-DOTATATE preparation. Recent Results in Cancer Research 194 : 177-188. ScholarBank@NUS Repository. https://doi.org/10.1007/978-3-642-27994-2-10||Abstract:||Neuroendocrine tumors (NETs) are a rare form of cancer. NETs frequently express cell membrane-specific peptide receptors, such as somatostatin receptors (SSTRs). Radiolabeled peptides bind to SSTR and provide in vivo histopathological information for diagnostic purposes. 68Ga-DOTATATE has higher sensitivity for low-grade tumors and greater avidity to well-differentiated NETs than 18F-FDG, being superior to 111In-DTPA-octreotide and 18F-DOPA in evaluation of well-differentiated metastatic NETs. The feasibility of 68Ga-DOTATATE application in routine clinical practice for PET imaging of NETs was determined in a limited number of known cases (n = 6). 68Ga-DOTATATE scan could detect all known sites of NETs and in one case previously unknown peritoneal metastasis. Early regulatory consideration is important for routine clinical use. © 2013 Springer-Verlag Berlin Heidelberg.||Source Title:||Recent Results in Cancer Research||URI:||http://scholarbank.nus.edu.sg/handle/10635/109310||ISBN:||9783642279935||ISSN:||00800015||DOI:||10.1007/978-3-642-27994-2-10|
|Appears in Collections:||Staff Publications|
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