Please use this identifier to cite or link to this item: https://doi.org/10.1111/his.12211
DC FieldValue
dc.titleDown-regulation of EMP1 is associated with epithelial hyperplasia and metaplasia in nasal polyps
dc.contributor.authorYu, X.M.
dc.contributor.authorLi, C.W.
dc.contributor.authorLi, Y.Y.
dc.contributor.authorLiu, J.
dc.contributor.authorLin, Z.B.
dc.contributor.authorLi, T.Y.
dc.contributor.authorZhao, L.
dc.contributor.authorPan, X.L.
dc.contributor.authorShi, L.
dc.contributor.authorWang, D.Y.
dc.date.accessioned2014-11-26T07:44:17Z
dc.date.available2014-11-26T07:44:17Z
dc.date.issued2013-11
dc.identifier.citationYu, X.M., Li, C.W., Li, Y.Y., Liu, J., Lin, Z.B., Li, T.Y., Zhao, L., Pan, X.L., Shi, L., Wang, D.Y. (2013-11). Down-regulation of EMP1 is associated with epithelial hyperplasia and metaplasia in nasal polyps. Histopathology 63 (5) : 686-695. ScholarBank@NUS Repository. https://doi.org/10.1111/his.12211
dc.identifier.issn03090167
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/109307
dc.description.abstractAims: The aim of this study was to assess protein and mRNA expression of epithelial membrane protein 1 (EMP1) in the nasal mucosa of patients with nasal polyps (NP), and to determine what changes occur in response to glucocorticosteroid (GC) treatment. Methods and results: NP tissue was obtained from 55 patients, 18 of whom were treated with nasal GCs (i.e. these 18 patients had NP biopsies taken before and after treatment). Biopsies of inferior turbinate mucosa from 30 healthy subjects were used as controls. Quantitative PCR and immunohistochemistry were performed to determine the expression levels of EMP1. EMP1 mRNA expression was significantly lower (2.77-fold) in tissues from NP patients before GC treatment when compared to controls, but was increased in these patients after GC treatment. EMP1 staining in nasal epithelium co-localized with both basal (p63+) and differentiated (CK18+) epithelial cells. Their immunoreactivity was significantly greater in controls than NP patients. EMP1 mRNA levels were lower in the epithelium with severe hyperplasia (1.79-fold) or with metaplasia (1.85-fold) as compared to those with mild to moderate hyperplasia or non-metaplastic epithelium, respectively. Positive correlations between EMP1 and other epithelial cell-related gene (e.g. JUN, PTGS2, AREG etc.) mRNAs were observed. Conclusions: EMP1 could be a biomarker for aberrant epithelial remodelling and metaplasia in chronic inflammatory upper airway mucosa (e.g. NP). © 2013 John Wiley & Sons Ltd635 November 2013 10.1111/his.12211 Original Article Original Articles © 2013 John Wiley & Sons Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1111/his.12211
dc.sourceScopus
dc.subjectEMP1
dc.subjectEpithelial hyperplasia or metaplasia
dc.subjectNasal epithelium
dc.subjectNasal polyposis
dc.typeArticle
dc.contributor.departmentOTOLARYNGOLOGY
dc.description.doi10.1111/his.12211
dc.description.sourcetitleHistopathology
dc.description.volume63
dc.description.issue5
dc.description.page686-695
dc.description.codenHISTD
dc.identifier.isiut000325545600009
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

20
checked on Mar 2, 2021

WEB OF SCIENCETM
Citations

21
checked on Mar 2, 2021

Page view(s)

97
checked on Feb 27, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.