Please use this identifier to cite or link to this item: https://doi.org/10.4161/cc.10.24.18567
DC FieldValue
dc.titleConservation of all three p53 family members and Mdm2 and Mdm4 in the cartilaginous fish
dc.contributor.authorLane, D.P.
dc.contributor.authorMadhumalar, A.
dc.contributor.authorLee, A.P.
dc.contributor.authorTay, B.-H.
dc.contributor.authorVerma, C.
dc.contributor.authorBrenner, S.
dc.contributor.authorVenkatesh, B.
dc.date.accessioned2014-11-26T07:43:50Z
dc.date.available2014-11-26T07:43:50Z
dc.date.issued2011-12-15
dc.identifier.citationLane, D.P., Madhumalar, A., Lee, A.P., Tay, B.-H., Verma, C., Brenner, S., Venkatesh, B. (2011-12-15). Conservation of all three p53 family members and Mdm2 and Mdm4 in the cartilaginous fish. Cell Cycle 10 (24) : 4272-4279. ScholarBank@NUS Repository. https://doi.org/10.4161/cc.10.24.18567
dc.identifier.issn15384101
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/109268
dc.description.abstractAnalysis of the genome of the elephant shark (Callorhinchus milii), a member of the cartilaginous fishes (Class Chondrichthyes), reveals that it encodes all three members of the p53 gene family, p53, p63 and p73, each with clear homology to the equivalent gene in bony vertebrates (Class Osteichthyes). Thus, the gene duplication events that lead to the presence of three family members in the vertebrates dates to before the Silurian era. It also encodes Mdm2 and Mdm4 genes but does not encode the p19 Arf gene. Detailed comparison of the amino acid sequences of these proteins in the vertebrates reveals that they are evolving at highly distinctive rates, and this variation occurs not only between the three family members but extends to distinct domains in each protein. © 2011 Landes Bioscience.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.4161/cc.10.24.18567
dc.sourceScopus
dc.subjectElephant shark
dc.subjectMdm2
dc.subjectMdm4
dc.subjectp53
dc.subjectp63
dc.subjectp73
dc.typeArticle
dc.contributor.departmentPAEDIATRICS
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.4161/cc.10.24.18567
dc.description.sourcetitleCell Cycle
dc.description.volume10
dc.description.issue24
dc.description.page4272-4279
dc.identifier.isiut000298407200028
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

25
checked on Jun 30, 2020

WEB OF SCIENCETM
Citations

23
checked on Jun 30, 2020

Page view(s)

151
checked on Jun 27, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.