Please use this identifier to cite or link to this item: https://doi.org/10.4161/cc.10.24.18567
Title: Conservation of all three p53 family members and Mdm2 and Mdm4 in the cartilaginous fish
Authors: Lane, D.P.
Madhumalar, A.
Lee, A.P.
Tay, B.-H.
Verma, C. 
Brenner, S.
Venkatesh, B. 
Keywords: Elephant shark
Mdm2
Mdm4
p53
p63
p73
Issue Date: 15-Dec-2011
Citation: Lane, D.P., Madhumalar, A., Lee, A.P., Tay, B.-H., Verma, C., Brenner, S., Venkatesh, B. (2011-12-15). Conservation of all three p53 family members and Mdm2 and Mdm4 in the cartilaginous fish. Cell Cycle 10 (24) : 4272-4279. ScholarBank@NUS Repository. https://doi.org/10.4161/cc.10.24.18567
Abstract: Analysis of the genome of the elephant shark (Callorhinchus milii), a member of the cartilaginous fishes (Class Chondrichthyes), reveals that it encodes all three members of the p53 gene family, p53, p63 and p73, each with clear homology to the equivalent gene in bony vertebrates (Class Osteichthyes). Thus, the gene duplication events that lead to the presence of three family members in the vertebrates dates to before the Silurian era. It also encodes Mdm2 and Mdm4 genes but does not encode the p19 Arf gene. Detailed comparison of the amino acid sequences of these proteins in the vertebrates reveals that they are evolving at highly distinctive rates, and this variation occurs not only between the three family members but extends to distinct domains in each protein. © 2011 Landes Bioscience.
Source Title: Cell Cycle
URI: http://scholarbank.nus.edu.sg/handle/10635/109268
ISSN: 15384101
DOI: 10.4161/cc.10.24.18567
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