Please use this identifier to cite or link to this item: https://doi.org/10.1186/1471-2334-11-123
Title: Confirmed adult dengue deaths in Singapore: 5-year multi-center retrospective study
Authors: Leo, Y.-S.
Thein, T.L.
Fisher, D.A.
Low, J.G.
Oh, H.M.
Narayanan, R.L.
Gan, V.C.
Lee, V.J. 
Lye, D.C.
Issue Date: 12-May-2011
Citation: Leo, Y.-S., Thein, T.L., Fisher, D.A., Low, J.G., Oh, H.M., Narayanan, R.L., Gan, V.C., Lee, V.J., Lye, D.C. (2011-05-12). Confirmed adult dengue deaths in Singapore: 5-year multi-center retrospective study. BMC Infectious Diseases 11 : -. ScholarBank@NUS Repository. https://doi.org/10.1186/1471-2334-11-123
Abstract: Background: Dengue re-emerges in Singapore despite decades of effective vector control; the infection predominantly afflicts adults. Severe dengue not fulfilling dengue hemorrhagic fever (DHF) criteria according to World Health Organization (WHO) 1997 guideline was increasingly reported. A new WHO 2009 guideline emphasized warning signs and a wider range of severe dengue manifestations. We aim to evaluate the utility of these two guidelines in confirmed adult dengue fatalities.Methods: We conducted a multi-center retrospective chart review of all confirmed adult dengue deaths in Singapore from 1 January 2004 to 31 December 2008.Results: Of 28 adult dengue deaths, median age was 59 years. Male gender comprised 67.9% and co-morbidities existed in 75%. From illness onset, patients presented for admission at a median of 4 days and death occurred at a median of 12 days. Intensive care admission was required in 71.4%. Probable dengue was diagnosed in 32.1% by WHO 1997 criteria and 78.6% by WHO 2009. The earliest warning sign was persistent vomiting at a median of 1.5 days. Hematocrit change ≥20% concurrent with platelet count
Source Title: BMC Infectious Diseases
URI: http://scholarbank.nus.edu.sg/handle/10635/109267
ISSN: 14712334
DOI: 10.1186/1471-2334-11-123
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