Please use this identifier to cite or link to this item: https://doi.org/10.1038/ncomms2864
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dc.titleCalfacilitin is a calcium channel modulator essential for initiation of neural plate development
dc.contributor.authorPapanayotou, C.
dc.contributor.authorDe Almeida, I.
dc.contributor.authorLiao, P.
dc.contributor.authorOliveira, N.M.M.
dc.contributor.authorLu, S.-Q.
dc.contributor.authorKougioumtzidou, E.
dc.contributor.authorZhu, L.
dc.contributor.authorShaw, A.
dc.contributor.authorSheng, G.
dc.contributor.authorStreit, A.
dc.contributor.authorYu, D.
dc.contributor.authorWah Soong, T.
dc.contributor.authorStern, C.D.
dc.date.accessioned2014-11-26T07:43:16Z
dc.date.available2014-11-26T07:43:16Z
dc.date.issued2013
dc.identifier.citationPapanayotou, C., De Almeida, I., Liao, P., Oliveira, N.M.M., Lu, S.-Q., Kougioumtzidou, E., Zhu, L., Shaw, A., Sheng, G., Streit, A., Yu, D., Wah Soong, T., Stern, C.D. (2013). Calfacilitin is a calcium channel modulator essential for initiation of neural plate development. Nature Communications 4 : -. ScholarBank@NUS Repository. https://doi.org/10.1038/ncomms2864
dc.identifier.issn20411723
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/109221
dc.description.abstractCalcium fluxes have been implicated in the specification of the vertebrate embryonic nervous system for some time, but how these fluxes are regulated and how they relate to the rest of the neural induction cascade is unknown. Here we describe Calfacilitin, a transmembrane calcium channel facilitator that increases calcium flux by generating a larger window current and slowing inactivation of the L-type Ca V 1.2 channel. Calfacilitin binds to this channel and is co-expressed with it in the embryo. Regulation of intracellular calcium by Calfacilitin is required for expression of the neural plate specifiers Geminin and Sox2 and for neural plate formation. Loss-of-function of Calfacilitin can be rescued by ionomycin, which increases intracellular calcium. Our results elucidate the role of calcium fluxes in early neural development and uncover a new factor in the modulation of calcium signalling. © 2013 Macmillan Publishers Limited. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1038/ncomms2864
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentPHYSIOLOGY
dc.description.doi10.1038/ncomms2864
dc.description.sourcetitleNature Communications
dc.description.volume4
dc.description.page-
dc.identifier.isiut000320589900033
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