Please use this identifier to cite or link to this item: https://doi.org/10.2147/OPTH.S47424
Title: Baseline central macular thickness predicts the need for retreatment with intravitreal triamcinolone plus laser photocoagulation for diabetic macular edema
Authors: O'Day, R.
Barthelmes, D.
Zhu, M.
Wong, T.Y. 
McAllister, I.L.
Arnold, J.J.
Gillies, M.C.
Keywords: Central macular thickness
Diabetic macular edema
Intravitreal triamcinolone
Issue Date: 1-Aug-2013
Citation: O'Day, R., Barthelmes, D., Zhu, M., Wong, T.Y., McAllister, I.L., Arnold, J.J., Gillies, M.C. (2013-08-01). Baseline central macular thickness predicts the need for retreatment with intravitreal triamcinolone plus laser photocoagulation for diabetic macular edema. Clinical Ophthalmology 7 : 1565-1570. ScholarBank@NUS Repository. https://doi.org/10.2147/OPTH.S47424
Abstract: Purpose: To identify baseline characteristics that predict the number of treatments with intravitreal triamcinolone acetonide (IVTA) plus laser photocoagulation needed to treat diabetic macular edema over a 2-year period. Methods: Individual data from 42 eyes of 42 participants treated with IVTA plus laser photocoagulation for diabetic macular edema during a prospective, randomized, double-masked, placebo-controlled trial were used for this post hoc analysis. Baseline characteristics - age, gender, best-corrected visual acuity, glycosylated hemoglobin, phakic status, intraocular pressure, and central macular thickness (CMT) - were correlated with the number of IVTA plus laser treatments received during the 2 years of this study. Results: The median number of treatments received over the 2-year period was 2.5 (interquartile range 1.0-3.0), with 21 (50%) eyes needing three or more treatments. Eyes that received more IVTA plus laser treatments had a higher mean baseline CMT and eyes with a higher baseline CMT were more likely to receive three or more treatments (odds ratio 5.13, 95% confidence interval 1.75-15.04, P=0.003 per 100 μm increase in CMT). No significant relationship was found between other baseline characteristics and the number of IVTA plus laser treatments received. Conclusion: Higher baseline CMT was strongly linked with receiving more IVTA plus laser treatments. These patients may be at higher risk of developing dose-dependent steroid-related adverse events, cataract progression, and intraocular pressure rise. © 2013 O'Day et al, publisher and licensee Dove Medical Press Ltd.
Source Title: Clinical Ophthalmology
URI: http://scholarbank.nus.edu.sg/handle/10635/109214
ISSN: 11775467
DOI: 10.2147/OPTH.S47424
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