Please use this identifier to cite or link to this item: https://doi.org/10.1167/iovs.12-11250
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dc.titleAssociations of iris structural measurements in a Chinese population: The Singapore Chinese eye study
dc.contributor.authorSng, C.C.
dc.contributor.authorAllen, J.C.
dc.contributor.authorNongpiur, M.E.
dc.contributor.authorFoo, L.-L.
dc.contributor.authorZheng, Y.
dc.contributor.authorCheung, C.Y.
dc.contributor.authorHe, M.
dc.contributor.authorFriedman, D.S.
dc.contributor.authorWong, T.Y.
dc.contributor.authorAung, T.
dc.date.accessioned2014-11-26T07:43:05Z
dc.date.available2014-11-26T07:43:05Z
dc.date.issued2013
dc.identifier.citationSng, C.C., Allen, J.C., Nongpiur, M.E., Foo, L.-L., Zheng, Y., Cheung, C.Y., He, M., Friedman, D.S., Wong, T.Y., Aung, T. (2013). Associations of iris structural measurements in a Chinese population: The Singapore Chinese eye study. Investigative Ophthalmology and Visual Science 54 (4) : 2829-2835. ScholarBank@NUS Repository. https://doi.org/10.1167/iovs.12-11250
dc.identifier.issn01460404
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/109205
dc.description.abstractPURPOSE. We determined the ocular biometric and demographic factors associated with iris parameters in Singaporean Chinese persons from a population-based sample. METHODS. Subjects were participants in the Singapore Chinese Eye Study, a population-based cross-sectional study of eye disease. Anterior segment optical coherence tomography images were analyzed using customized software to measure iris thickness at 750 lm from the scleral spur (IT750), iris area (I-Area), and iris curvature (I-Curv). Regression analyses were performed to assess the association between iris measurements with a range of demographic and ocular variables. The contribution of each independent variable to the iris parameter of interest was determined sequentially using a stepwise selection algorithm. RESULTS. We included 1473 participants with a mean age of 57.7 ± 8.68 years, and 50.6% were men. The mean IT750, I-Area, and I-Curv were 0.46 ± 0.10 mm, 1.49 ± 0.24 mm2, and 0.25 ± 0.13 mm, respectively. Statistical regression models, including a range of demographic and ocular parameters, explained 59.3%, 41.9%, and 34.3% of the variability in I-Curv, IT750, and I-Area, respectively. Angle opening distance at 750 μm from the scleral spur (AOD750) was the single factor associated most strongly with I-Curv, and explained 46.6% of its variation. CONCLUSIONS. A significant proportion of the variation in iris area, curvature, and thickness was not explained by other ocular and demographic parameters. Iris curvature was associated strongly with angle width, and of all parameters investigated, AOD750 was most highly correlated with iris curvature. © 2013 The Association for Research in Vision and Ophthalmology, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1167/iovs.12-11250
dc.sourceScopus
dc.subjectAngle closure
dc.subjectEpidemiology
dc.subjectIris
dc.subjectOptical coherence tomography
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.contributor.departmentOPHTHALMOLOGY
dc.description.doi10.1167/iovs.12-11250
dc.description.sourcetitleInvestigative Ophthalmology and Visual Science
dc.description.volume54
dc.description.issue4
dc.description.page2829-2835
dc.description.codenIOVSD
dc.identifier.isiut000319821700051
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