Please use this identifier to cite or link to this item:
https://doi.org/10.1001/archopht.125.1.68
DC Field | Value | |
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dc.title | Apolipoprotein E gene and age-related maculopathy in older individuals: The Cardiovascular Health Study | |
dc.contributor.author | Tikellis, G. | |
dc.contributor.author | Sun, C. | |
dc.contributor.author | Gorin, M.B. | |
dc.contributor.author | Klein, R. | |
dc.contributor.author | Klein, B.E.K. | |
dc.contributor.author | Larsen, E.K.M. | |
dc.contributor.author | Siscovick, D.S. | |
dc.contributor.author | Hubbard, L.D. | |
dc.contributor.author | Wong, T.Y. | |
dc.date.accessioned | 2014-11-26T07:42:49Z | |
dc.date.available | 2014-11-26T07:42:49Z | |
dc.date.issued | 2007-01 | |
dc.identifier.citation | Tikellis, G., Sun, C., Gorin, M.B., Klein, R., Klein, B.E.K., Larsen, E.K.M., Siscovick, D.S., Hubbard, L.D., Wong, T.Y. (2007-01). Apolipoprotein E gene and age-related maculopathy in older individuals: The Cardiovascular Health Study. Archives of Ophthalmology 125 (1) : 68-73. ScholarBank@NUS Repository. https://doi.org/10.1001/archopht.125.1.68 | |
dc.identifier.issn | 00039950 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/109183 | |
dc.description.abstract | Objective: To examine the association between the apolipoprotein E (APOE) gene and age-related maculopathy (ARM) in an older population. Methods: Two thousand one hundred seventy persons 65 years and older sampled from 4 US communities had ARM signs assessed from retinal photographs using a modified Wisconsin Age-Related Maculopathy Grading System. DNA extracted from blood samples was analyzed for common APOE alleles. Results: After controlling for age, sex, cigarette smoking, and other factors, white participants carrying the ε2 allele had an increased risk of late ARM (odds ratio, 2.53 [95% confidence interval, 1.08-5.90]) while carriers of the ε4 allele had a lower risk of late ARM (odds ratio, 0.69 [95% confidence interval, 0.19-2.50]). There were too few late ARM cases in African American individuals for analysis. Conclusion: APOE polymorphism is associated with late ARM in older white persons 65 years and older. Consistent with previous studies, the APOE ε2 allele is associated with a significant increased risk of late ARM development, whereas the ε4 allele may confer some protection. ©2007 American Medical Association. All rights reserved. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1001/archopht.125.1.68 | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | OPHTHALMOLOGY | |
dc.description.doi | 10.1001/archopht.125.1.68 | |
dc.description.sourcetitle | Archives of Ophthalmology | |
dc.description.volume | 125 | |
dc.description.issue | 1 | |
dc.description.page | 68-73 | |
dc.description.coden | AROPA | |
dc.identifier.isiut | 000243336800009 | |
Appears in Collections: | Staff Publications |
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