Please use this identifier to cite or link to this item: https://doi.org/10.1001/archopht.125.1.68
Title: Apolipoprotein E gene and age-related maculopathy in older individuals: The Cardiovascular Health Study
Authors: Tikellis, G.
Sun, C.
Gorin, M.B.
Klein, R.
Klein, B.E.K.
Larsen, E.K.M.
Siscovick, D.S.
Hubbard, L.D.
Wong, T.Y. 
Issue Date: Jan-2007
Citation: Tikellis, G., Sun, C., Gorin, M.B., Klein, R., Klein, B.E.K., Larsen, E.K.M., Siscovick, D.S., Hubbard, L.D., Wong, T.Y. (2007-01). Apolipoprotein E gene and age-related maculopathy in older individuals: The Cardiovascular Health Study. Archives of Ophthalmology 125 (1) : 68-73. ScholarBank@NUS Repository. https://doi.org/10.1001/archopht.125.1.68
Abstract: Objective: To examine the association between the apolipoprotein E (APOE) gene and age-related maculopathy (ARM) in an older population. Methods: Two thousand one hundred seventy persons 65 years and older sampled from 4 US communities had ARM signs assessed from retinal photographs using a modified Wisconsin Age-Related Maculopathy Grading System. DNA extracted from blood samples was analyzed for common APOE alleles. Results: After controlling for age, sex, cigarette smoking, and other factors, white participants carrying the ε2 allele had an increased risk of late ARM (odds ratio, 2.53 [95% confidence interval, 1.08-5.90]) while carriers of the ε4 allele had a lower risk of late ARM (odds ratio, 0.69 [95% confidence interval, 0.19-2.50]). There were too few late ARM cases in African American individuals for analysis. Conclusion: APOE polymorphism is associated with late ARM in older white persons 65 years and older. Consistent with previous studies, the APOE ε2 allele is associated with a significant increased risk of late ARM development, whereas the ε4 allele may confer some protection. ©2007 American Medical Association. All rights reserved.
Source Title: Archives of Ophthalmology
URI: http://scholarbank.nus.edu.sg/handle/10635/109183
ISSN: 00039950
DOI: 10.1001/archopht.125.1.68
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