Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.biocel.2010.12.017
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dc.title | Activation of a non-genomic Pim-1/Bad-Pser75 module is required for an efficient pro-survival effect of Bcl-xL induced by androgen in LNCaP cells | |
dc.contributor.author | Kumar, J.K. | |
dc.contributor.author | Ping, R.Y.S. | |
dc.contributor.author | Teong, H.F. | |
dc.contributor.author | Goh, S. | |
dc.contributor.author | Clément, M.-V. | |
dc.date.accessioned | 2014-11-26T07:42:31Z | |
dc.date.available | 2014-11-26T07:42:31Z | |
dc.date.issued | 2011-04 | |
dc.identifier.citation | Kumar, J.K., Ping, R.Y.S., Teong, H.F., Goh, S., Clément, M.-V. (2011-04). Activation of a non-genomic Pim-1/Bad-Pser75 module is required for an efficient pro-survival effect of Bcl-xL induced by androgen in LNCaP cells. International Journal of Biochemistry and Cell Biology 43 (4) : 594-603. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biocel.2010.12.017 | |
dc.identifier.issn | 13572725 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/109155 | |
dc.description.abstract | The present report investigated the pathway(s) involved in the inhibition of apoptosis by the synthetic androgen, R1881 in serum-starved LNCaP cells exposed to the pi3K inhibitor, LY294002. R1881 blocked LY294002-induced apoptosis through the inhibition of Bak activation via an increase in Bcl-xL transcription and protein expression. In addition, R1881 treatment enhanced the stability of the Pim-1 kinase, resulting in the inhibition of the activation of the BH3-only protein Bad through its phosphorylation at ser75. Pharmacological inhibition of the Pim-1 kinase activity with quercetagetin, a highly selective Pim-1 inhibitor, prevented R1881-mediated increase in Bad phosphorylation and restored cell sensitivity to LY294002-induced apoptosis despite the increase in Bcl-xL expression. These results demonstrate for the first time that the inhibition of LY294002-induced apoptosis by androgen is a function of an androgen receptor-dependent genomic signaling pathway leading to an increase in Bcl-xL expression as well as a non-genomic, Pim-1-dependent, signaling pathway mediated via phosphorylation of Bad at ser75. © 2010 Elsevier Ltd. All rights reserved. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.biocel.2010.12.017 | |
dc.source | Scopus | |
dc.subject | Bad | |
dc.subject | Bcl-xL | |
dc.subject | LY294002 | |
dc.subject | Pim-1 | |
dc.subject | Prostate cancer | |
dc.type | Article | |
dc.contributor.department | BIOCHEMISTRY | |
dc.description.doi | 10.1016/j.biocel.2010.12.017 | |
dc.description.sourcetitle | International Journal of Biochemistry and Cell Biology | |
dc.description.volume | 43 | |
dc.description.issue | 4 | |
dc.description.page | 594-603 | |
dc.description.coden | IJBBF | |
dc.identifier.isiut | 000288736800019 | |
Appears in Collections: | Staff Publications |
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