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Title: Validity of a new optic disc grading software for use in clinical and epidemiological research
Authors: Tham, Y.-C.
Cheung, C.Y. 
Wong, T.Y. 
Baskaran, M.
Liu, J.
Lee, B.-H.
Yin, F.
Wong, D.W.
Wang, J.J.
Mitchell, P.
Aung, T.
Cheng, C.-Y. 
Keywords: Epidemiology
Optic disc
Optic nerve evaluation
Issue Date: Dec-2013
Citation: Tham, Y.-C., Cheung, C.Y., Wong, T.Y., Baskaran, M., Liu, J., Lee, B.-H., Yin, F., Wong, D.W., Wang, J.J., Mitchell, P., Aung, T., Cheng, C.-Y. (2013-12). Validity of a new optic disc grading software for use in clinical and epidemiological research. Clinical and Experimental Ophthalmology 41 (9) : 842-852. ScholarBank@NUS Repository.
Abstract: Background: To determine the reliability and agreement of a new optic disc grading software program for use in clinical, epidemiological research. Design: Reliability and agreement study. Samples: 328 monoscopic and 85 stereoscopic optic disc images. Methods: Optic disc parameters were measured using a new optic disc grading software (Singapore Optic Disc Assessment) that is based on polynomial curve-fitting algorithm. Two graders independently graded 328 monoscopic images to determine intergrader reliability. One grader regraded the images after 1 month to determine intragrader reliability. In addition, 85 stereo optic disc images were separately selected, and vertical cup-to-disc ratios were measured using both the new software and standardized Wisconsin manual stereo-grading method by the same grader 1 month apart. Intraclass correlation coefficient (ICC) and Bland-Altman plot analyses were performed. Main Outcome Measures: Optic disc parameters. Results: The intragrader and intergrader reliability for optic disc measurements using Singapore Optic Disc Assessment was high (ICC ranging from 0.82 to 0.94). The mean differences (95% limits of agreement) for intergrader vertical cup-to-disc ratio measurements were 0.00 (-0.12 to 0.13) and 0.03 (-0.15 to 0.09), respectively. The vertical cup-to-disc ratio agreement between the software and Wisconsin grading method was extremely close (ICC=0.94). The mean difference (95% limits of agreement) of vertical cup-to-disc ratio measurement between the two methods was 0.03 (-0.09 to 0.16). Conclusions: Intragrader and intergrader reliability using Singapore Optic Disc Assessment was excellent. This software was highly comparable with standardized stereo-grading method. Singapore Optic Disc Assessment is useful for grading digital optic disc images in clinical, population-based studies. © 2013 Royal Australian and New Zealand College of Ophthalmologists.
Source Title: Clinical and Experimental Ophthalmology
ISSN: 14426404
DOI: 10.1111/ceo.12112
Appears in Collections:Staff Publications

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