Please use this identifier to cite or link to this item:
Title: Role of dietary long-chain polyunsaturated fatty acids in infant allergies and respiratory diseases
Authors: Shek, L.P.
Chong, M.F.-F.
Lim, J.Y.
Soh, S.-E. 
Chong, Y.-S.
Issue Date: 2012
Citation: Shek, L.P., Chong, M.F.-F., Lim, J.Y., Soh, S.-E., Chong, Y.-S. (2012). Role of dietary long-chain polyunsaturated fatty acids in infant allergies and respiratory diseases. Clinical and Developmental Immunology 2012 : -. ScholarBank@NUS Repository.
Abstract: Maternal nutrition has critical effects on the developing structures and functions of the fetus. Malnutrition during pregnancy can result in low birth weight and small for gestational age babies, increase risk for infection, and impact the immune system. Long-chain polyunsaturated fatty acids (PUFAs) have been reported to have immunomodulatory effects. Decreased consumption of omega-6 PUFAs, in favor of more anti-inflammatory omega-3 PUFAs in modern diets, has demonstrated the potential protective role of omega-3 PUFAs in allergic and respiratory diseases. In this paper, we examine the role of PUFAs consumption during pregnancy and early childhood and its influence on allergy and respiratory diseases. PUFAs act via several mechanisms to modulate immune function. Omega-3 PUFAs may alter the T helper (Th) cell balance by inhibiting cytokine production which in turn inhibits immunoglobulin E synthesis and Th type 2 cell differentiation. PUFAs may further modify cellular membrane, induce eicosanoid metabolism, and alter gene expression. These studies indicate the benefits of omega-3 PUFAs supplementation. Nevertheless, further investigations are warranted to assess the long-term effects of omega-3 PUFAs in preventing other immune-mediated diseases, as well as its effects on the later immunodefense and health status during early growth and development. © 2012 Lynette P. Shek et al.
Source Title: Clinical and Developmental Immunology
ISSN: 17402522
DOI: 10.1155/2012/730568
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
730568.pdf1.21 MBAdobe PDF




checked on Jun 7, 2021


checked on Jun 7, 2021

Page view(s)

checked on Jun 7, 2021


checked on Jun 7, 2021

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.