Please use this identifier to cite or link to this item: https://doi.org/10.1097/HJH.0000000000000096
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dc.titleMaternal adiposity and blood pressure in pregnancy: Varying relations by ethnicity and gestational diabetes
dc.contributor.authorLim, W.-Y.
dc.contributor.authorKwek, K.
dc.contributor.authorChong, Y.-S.
dc.contributor.authorLee, Y.-S.
dc.contributor.authorYap, F.
dc.contributor.authorChan, Y.-H.
dc.contributor.authorGodfrey, K.M.
dc.contributor.authorGluckman, P.D.
dc.contributor.authorSaw, S.-M.
dc.contributor.authorPan, A.
dc.date.accessioned2014-11-26T05:04:03Z
dc.date.available2014-11-26T05:04:03Z
dc.date.issued2014-04
dc.identifier.citationLim, W.-Y., Kwek, K., Chong, Y.-S., Lee, Y.-S., Yap, F., Chan, Y.-H., Godfrey, K.M., Gluckman, P.D., Saw, S.-M., Pan, A. (2014-04). Maternal adiposity and blood pressure in pregnancy: Varying relations by ethnicity and gestational diabetes. Journal of Hypertension 32 (4) : 857-864. ScholarBank@NUS Repository. https://doi.org/10.1097/HJH.0000000000000096
dc.identifier.issn14735598
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/108985
dc.description.abstractOBJECTIVE:: Greater maternal adiposity is a potentially modifiable risk factor for elevated blood pressure during pregnancy; however, the association has been little studied in Asian populations, and no study has evaluated potential differences in the adiposity-blood pressure relation between ethnic groups or interaction with gestational diabetes. METHODS:: We performed a cross-sectional evaluation of a Singapore mother-offspring cohort comprising 799 pregnant Chinese, Malay and Indian women. Data on body weight, height, skinfold thickness and glycaemia (oral glucose tolerance test) were collected during the 2nd trimester; peripheral SBP and DBP were measured using an oscillometric device and central pressures by noninvasive radial applanation tonometry. The associations between adiposity measures BMI and sum of skinfold thickness and blood pressure outcomes were examined by linear regression with adjustment for potential confounders. RESULTS:: Higher maternal BMI was associated with elevated peripheral and central pressures: the increases in pressure (mmHg) for each kg/m increase in BMI were 1.19 (95% confidence interval, 1.03-1.36) for peripheral SBP, 0.76 (0.63-0.89) for peripheral DBP, 1.02 (0.87-1.17) for central systolic pressure and 0.26 (0.16-0.37) for central pulse pressure. The associations were generally stronger in Chinese women (P-interaction=0.03 for central pulse pressure) and individuals with gestational diabetes (P-interaction=0.03 for DBP and P-interaction=0.046 for central systolic pressure). Similar patterns of results were found when using skinfold thickness as the measure of adiposity. CONCLUSION:: Maternal adiposity is associated with higher peripheral and central blood pressures during pregnancy. Stronger associations in Chinese women and individuals with gestational diabetes warrant further investigation. Copyright © Lippincott Williams & Wilkins.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1097/HJH.0000000000000096
dc.sourceScopus
dc.subjectCentral blood pressure
dc.subjectEthnicity
dc.subjectGestational diabetes
dc.subjectObesity
dc.subjectPeripheral blood pressure
dc.subjectPregnancy
dc.typeArticle
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.description.doi10.1097/HJH.0000000000000096
dc.description.sourcetitleJournal of Hypertension
dc.description.volume32
dc.description.issue4
dc.description.page857-864
dc.description.codenJOHYD
dc.identifier.isiut000333301000022
dc.published.statePublished
dc.grant.idNMRC/TCR/004-NUS/2008
dc.grant.idNMRC/TCR/012-NUHS/2014
dc.grant.fundingagencyNational Medical Research Council
dc.description.seriesGUSTO (Growing up towards Healthy Outcomes)
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