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dc.titleHLA-B*13:01 and the dapsone hypersensitivity syndrome
dc.contributor.authorZhang, F.-R.
dc.contributor.authorLiu, H.
dc.contributor.authorIrwanto, A.
dc.contributor.authorFu, X.-A.
dc.contributor.authorLi, Y.
dc.contributor.authorYu, G.-Q.
dc.contributor.authorYu, Y.-X.
dc.contributor.authorChen, M.-F.
dc.contributor.authorLow, H.-Q.
dc.contributor.authorLi, J.-H.
dc.contributor.authorBao, F.-F.
dc.contributor.authorFoo, J.-N.
dc.contributor.authorBei, J.-X.
dc.contributor.authorJia, X.-M.
dc.contributor.authorLiu, J.
dc.contributor.authorLiany, H.
dc.contributor.authorWang, N.
dc.contributor.authorNiu, G.-Y.
dc.contributor.authorWang, Z.-Z.
dc.contributor.authorShi, B.-Q.
dc.contributor.authorTian, H.-Q.
dc.contributor.authorLiu, H.-X.
dc.contributor.authorMa, S.-S.
dc.contributor.authorZhou, Y.
dc.contributor.authorYou, J.-B.
dc.contributor.authorYang, Q.
dc.contributor.authorWang, C.
dc.contributor.authorChu, T.-S.
dc.contributor.authorLiu, D.-C.
dc.contributor.authorYu, X.-L.
dc.contributor.authorSun, Y.-H.
dc.contributor.authorNing, Y.
dc.contributor.authorWei, Z.-H.
dc.contributor.authorChen, S.-L.
dc.contributor.authorChen, X.-C.
dc.contributor.authorZhang, Z.-X.
dc.contributor.authorLiu, Y.-X.
dc.contributor.authorPulit, S.L.
dc.contributor.authorWu, W.-B.
dc.contributor.authorZheng, Z.-Y.
dc.contributor.authorYang, R.-D.
dc.contributor.authorLong, H.
dc.contributor.authorLiu, Z.-S.
dc.contributor.authorWang, J.-Q.
dc.contributor.authorLi, M.
dc.contributor.authorZhang, L.-H.
dc.contributor.authorWang, H.
dc.contributor.authorWang, L.-M.
dc.contributor.authorXiao, P.
dc.contributor.authorLi, J.-L.
dc.contributor.authorHuang, Z.-M.
dc.contributor.authorHuang, J.-X.
dc.contributor.authorLi, Z.
dc.contributor.authorLiu, J.
dc.contributor.authorXiong, L.
dc.contributor.authorYang, J.
dc.contributor.authorWang, X.-D.
dc.contributor.authorYu, D.-B.
dc.contributor.authorLu, X.-M.
dc.contributor.authorZhou, G.-Z.
dc.contributor.authorYan, L.-B.
dc.contributor.authorShen, J.-P.
dc.contributor.authorZhang, G.-C.
dc.contributor.authorZeng, Y.-X.
dc.contributor.authorDe Bakker, P.I.W.
dc.contributor.authorChen, S.-M.
dc.contributor.authorLiu, J.-J.
dc.identifier.citationZhang, F.-R., Liu, H., Irwanto, A., Fu, X.-A., Li, Y., Yu, G.-Q., Yu, Y.-X., Chen, M.-F., Low, H.-Q., Li, J.-H., Bao, F.-F., Foo, J.-N., Bei, J.-X., Jia, X.-M., Liu, J., Liany, H., Wang, N., Niu, G.-Y., Wang, Z.-Z., Shi, B.-Q., Tian, H.-Q., Liu, H.-X., Ma, S.-S., Zhou, Y., You, J.-B., Yang, Q., Wang, C., Chu, T.-S., Liu, D.-C., Yu, X.-L., Sun, Y.-H., Ning, Y., Wei, Z.-H., Chen, S.-L., Chen, X.-C., Zhang, Z.-X., Liu, Y.-X., Pulit, S.L., Wu, W.-B., Zheng, Z.-Y., Yang, R.-D., Long, H., Liu, Z.-S., Wang, J.-Q., Li, M., Zhang, L.-H., Wang, H., Wang, L.-M., Xiao, P., Li, J.-L., Huang, Z.-M., Huang, J.-X., Li, Z., Liu, J., Xiong, L., Yang, J., Wang, X.-D., Yu, D.-B., Lu, X.-M., Zhou, G.-Z., Yan, L.-B., Shen, J.-P., Zhang, G.-C., Zeng, Y.-X., De Bakker, P.I.W., Chen, S.-M., Liu, J.-J. (2013). HLA-B*13:01 and the dapsone hypersensitivity syndrome. New England Journal of Medicine 369 (17) : 1620-1628. ScholarBank@NUS Repository.
dc.description.abstractBACKGROUND: Dapsone is used in the treatment of infections and inflammatory diseases. The dapsone hypersensitivity syndrome, which is associated with a reported mortality of 9.9%, develops in about 0.5 to 3.6% of persons treated with the drug. Currently, no tests are available to predict the risk of the dapsone hypersensitivity syndrome. METHODS: We performed a genomewide association study involving 872 participants who had received dapsone as part of multidrug therapy for leprosy (39 participants with the dapsone hypersensitivity syndrome and 833 controls), using log-additive tests of single-nucleotide polymorphisms (SNPs) and imputed HLA molecules. For a replication analysis, we genotyped 24 SNPs in an additional 31 participants with the dapsone hypersensitivity syndrome and 1089 controls and performed next-generation sequencing for HLA-B and HLA-C typing at four-digit resolution in an independent series of 37 participants with the dapsone hypersensitivity syndrome and 201 controls. RESULTS: Genomewide association analysis showed that SNP rs2844573, located between the HLA-B and MICA loci, was significantly associated with the dapsone hypersensitivity syndrome among patients with leprosy (odds ratio, 6.18; P = 3.84×10-13). HLAB*13:01 was confirmed to be a risk factor for the dapsone hypersensitivity syndrome (odds ratio, 20.53; P = 6.84×10-25). The presence of HLA-B*13:01 had a sensitivity of 85.5% and a specificity of 85.7% as a predictor of the dapsone hypersensitivity syndrome, and its absence was associated with a reduction in risk by a factor of 7 (from 1.4% to 0.2%). HLA-B*13:01 is present in about 2 to 20% of Chinese persons, 1.5% of Japanese persons, 1 to 12% of Indians, and 2 to 4% of Southeast Asians but is largely absent in Europeans and Africans. CONCLUSIONS: HLA-B*13:01 was associated with the development of the dapsone hypersensitivity syndrome among patients with leprosy. Copyright © 2013 Massachusetts Medical Society.
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.description.sourcetitleNew England Journal of Medicine
Appears in Collections:Staff Publications

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