Please use this identifier to cite or link to this item:
Title: Branch retinal vein occlusion and optic nerve head topographic parameters: The Singapore Indian eye study
Authors: Chan, E.W.
Wong, T.Y. 
Liao, J.
Cheung, C.Y.-I.
Zheng, Y.F.
Wang, J.J.
Mitchell, P.
Loon, S.C.
Saw, S.-M. 
Aung, T.
Cheng, C.-Y. 
Issue Date: May-2013
Citation: Chan, E.W., Wong, T.Y., Liao, J., Cheung, C.Y.-I., Zheng, Y.F., Wang, J.J., Mitchell, P., Loon, S.C., Saw, S.-M., Aung, T., Cheng, C.-Y. (2013-05). Branch retinal vein occlusion and optic nerve head topographic parameters: The Singapore Indian eye study. British Journal of Ophthalmology 97 (5) : 611-616. ScholarBank@NUS Repository.
Abstract: Aim To examine the association between branch retinal vein occlusion (BRVO) and quantitative optic disc topographic parameters. Methods The Singapore Indian Eye Study (SINDI) is a population-based study of 3400 Singapore Indians aged 40+ years. BRVO was defined and graded from retinal photographs. Optic disc parameters were quantified using the Heidelberg Retinal Tomograph III (HRT III). Associations were evaluated for individual eyes; the generalised estimating equation was used to account for correlation between fellow eyes. Results 6173 eyes (comprising 19 BRVO) had gradable retinal photographs and HRT images. After controlling for age, gender, and systemic (hypertension, diabetes, myocardial infarction) and ocular factors (intraocular pressure, glaucoma, central corneal thickness, axial length, previous laser photocoagulation), BRVO was associated with larger optic disc area (OR highest vs lowest tertile, 4.70; 95% CI 1.00 to 22.01; p=0.036), larger cup area (OR highest vs lowest tertile, 4.80; 95% CI 1.03 to 22.35; p=0.029) and larger cup-disc area ratio (OR highest vs lowest tertile, 4.44; 95% CI 0.95 to 20.66; p=0.037). After excluding glaucoma eyes, BRVO remained significantly associated with these parameters (p=0.027, p=0.018, p=0.024, respectively). Conclusions Quantitative optic disc parameters (optic cup and disc area) are associated with BRVO, even in non-glaucomatous eyes. Optic nerve head morphology may play a role in BRVO pathogenesis.
Source Title: British Journal of Ophthalmology
ISSN: 00071161
DOI: 10.1136/bjophthalmol-2012-302280
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Oct 18, 2021


checked on Oct 18, 2021

Page view(s)

checked on Oct 14, 2021

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.