Please use this identifier to cite or link to this item: https://doi.org/10.1093/jac/dkt055
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dc.titleAn elevated pro-inflammatory cytokine response is linked to development of amphotericin B-induced nephrotoxicity
dc.contributor.authorChai, L.Y.A.
dc.contributor.authorNetea, M.G.
dc.contributor.authorTai, B.C.
dc.contributor.authorKhin, L.W.
dc.contributor.authorVonk, A.G.
dc.contributor.authorTeo, B.W.
dc.contributor.authorSchlamm, H.T.
dc.contributor.authorHerbrecht, R.
dc.contributor.authorDonnelly, J.P.
dc.contributor.authorTroke, P.F.
dc.contributor.authorKullberg, B.-J.
dc.date.accessioned2014-11-26T05:02:18Z
dc.date.available2014-11-26T05:02:18Z
dc.date.issued2013
dc.identifier.citationChai, L.Y.A., Netea, M.G., Tai, B.C., Khin, L.W., Vonk, A.G., Teo, B.W., Schlamm, H.T., Herbrecht, R., Donnelly, J.P., Troke, P.F., Kullberg, B.-J. (2013). An elevated pro-inflammatory cytokine response is linked to development of amphotericin B-induced nephrotoxicity. Journal of Antimicrobial Chemotherapy 68 (7) : 1655-1659. ScholarBank@NUS Repository. https://doi.org/10.1093/jac/dkt055
dc.identifier.issn03057453
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/108867
dc.description.abstractObjectives: The underlying mechanism for amphotericin B-induced acute kidney injury (AKI) remains poorly understood and may be immunologically mediated. We assessed whether the development of nephrotoxicity is linked to a distinct cytokine profile in patients receiving amphotericin B deoxycholate (AmBD). Patients and methods: In 58 patients who received AmBD, circulating serum interleukin (IL)-6, IL-8 and IL-10 were measured at baseline, week 1 and week 2 of antifungal treatment and correlated to the development of renal impairment. The Cox proportional hazards model approach was adopted for analysis. Results: The P value was 0.026 for the overall effect of IL-6 on time to development of AKI. An increasing or nonreceding IL-6 trend by week 1 of AmBD treatment (followed by a decreasing or non-receding IL-6 trend fromweek 1 to week 2) correlated with an increased likelihood of nephrotoxicity [hazard ratio (HR) 6.93, P value 0.005 and HR 3.46, P value 0.035, respectively]. Similarly, persistently increasing IL-8 levels were linked to a 3.84-fold increased likelihood of AKI. Conclusions: In patients receiving AmBD, persistence of an elevated pro-inflammatory cytokine milieu is associated with a predisposition to drug-related kidney injury. © The Author 2013. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.
dc.sourceScopus
dc.subjectAcute kidney injury
dc.subjectDrug induced
dc.subjectImmune responses
dc.subjectInterleukins
dc.typeArticle
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.description.doi10.1093/jac/dkt055
dc.description.sourcetitleJournal of Antimicrobial Chemotherapy
dc.description.volume68
dc.description.issue7
dc.description.page1655-1659
dc.description.codenJACHD
dc.identifier.isiut000320452200030
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