Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ejca.2012.01.034
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dc.titleAdjuvant! Online is overoptimistic in predicting survival of Asian breast cancer patients
dc.contributor.authorBhoo-Pathy, N.
dc.contributor.authorYip, C.-H.
dc.contributor.authorHartman, M.
dc.contributor.authorSaxena, N.
dc.contributor.authorTaib, N.A.
dc.contributor.authorHo, G.-F.
dc.contributor.authorLooi, L.-M.
dc.contributor.authorBulgiba, A.M.
dc.contributor.authorGraaf, Y.V.D.
dc.contributor.authorVerkooijen, H.M.
dc.date.accessioned2014-11-26T05:02:15Z
dc.date.available2014-11-26T05:02:15Z
dc.date.issued2012-05
dc.identifier.citationBhoo-Pathy, N., Yip, C.-H., Hartman, M., Saxena, N., Taib, N.A., Ho, G.-F., Looi, L.-M., Bulgiba, A.M., Graaf, Y.V.D., Verkooijen, H.M. (2012-05). Adjuvant! Online is overoptimistic in predicting survival of Asian breast cancer patients. European Journal of Cancer 48 (7) : 982-989. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ejca.2012.01.034
dc.identifier.issn09598049
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/108863
dc.description.abstractBackground: Adjuvant! Online is a free web-based tool which predicts 10-year breast cancer outcomes and the efficacy of adjuvant therapy in patients with breast cancer. As its prognostic performance has only been validated in high income Caucasian populations, we validated the model in a middle income Asian setting. Methods: Within the University Malaya Hospital-Based Breast Cancer Registry, all 631 women who were surgically treated for invasive non-metastatic breast cancer between 1993 and 2000 were identified. The discriminative performance of Adjuvant! Online was tested using receiver operating characteristic (ROC) analysis. Calibration of the model was evaluated by comparing predicted 10-year overall survival with observed 10-year survival. Findings: Adjuvant! Online was fairly capable in discriminating between good and poor survivors, as attested by the area under ROC curve of 0.73 (95% Confidence Interval: 0.69-0.77). Overall, Adjuvant! Online predicted 10 year survival (70.3%) was significantly higher than the observed 10 year survival (63.6%, difference of 6.7%; 95% CI: 3.0-10.4%). The model was especially overoptimistic in women under 40 years and in women of Malay ethnicity, where survival was overestimated by approximately 20% (95% CI: 9.8-29.8%) and 15% (95% CI: 5.3-24.5%) respectively. Interpretation: Even though Adjuvant! Online is capable of discriminating between good and poor survivors, it systematically overestimates survival. These findings suggest that the model requires adaptation prior to use in Asian settings. © 2012 Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.ejca.2012.01.034
dc.sourceScopus
dc.subjectAsia
dc.subjectBreast cancer
dc.subjectPrognostication tool
dc.typeArticle
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.description.doi10.1016/j.ejca.2012.01.034
dc.description.sourcetitleEuropean Journal of Cancer
dc.description.volume48
dc.description.issue7
dc.description.page982-989
dc.description.codenEJCAE
dc.identifier.isiut000302779700004
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