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Title: Host-pathogen interactions revealed by human genome-wide surveys
Authors: Khor, C.C. 
Hibberd, M.L. 
Issue Date: May-2012
Citation: Khor, C.C., Hibberd, M.L. (2012-05). Host-pathogen interactions revealed by human genome-wide surveys. Trends in Genetics 28 (5) : 233-243. ScholarBank@NUS Repository.
Abstract: Genome-wide association studies (GWAS) have now convincingly shown that the diverse outcomes (such as the resolution of infection, clinical deterioration to severe disease, or progression from acute infection to persistent infection) that occur following microbial infection can be at least partly explained by human genetic variation. Unbiased whole-genome approaches have revealed unprecedentedly robust associations between genetic markers and susceptibility to disease, providing clear insights into our understanding of infectious disease biology by revealing the crucial host-pathogen interaction sites. Further work characterizing both the host causative variations and pathogenic microbial strains with distinct host interactions and disease outcomes is now required to provide potential new intervention strategies. © 2012 Elsevier Ltd.
Source Title: Trends in Genetics
ISSN: 01689525
DOI: 10.1016/j.tig.2012.02.001
Appears in Collections:Staff Publications

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