Please use this identifier to cite or link to this item: https://doi.org/10.1038/ng.1051
Title: Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways
Authors: Stolk, L.
Perry, J.R.B.
Chasman, D.I.
He, C.
Mangino, M.
Sulem, P.
Barbalic, M.
Broer, L.
Byrne, E.M.
Ernst, F.
Esko, T.
Franceschini, N.
Gudbjartsson, D.F.
Hottenga, J.-J.
Kraft, P.
McArdle, P.F.
Porcu, E.
Shin, S.-Y.
Smith, A.V.
Van Wingerden, S.
Zhai, G.
Zhuang, W.V.
Albrecht, E.
Alizadeh, B.Z.
Aspelund, T.
Bandinelli, S.
Lauc, L.B.
Beckmann, J.S.
Boban, M.
Boerwinkle, E.
Broekmans, F.J.
Burri, A.
Campbell, H.
Chanock, S.J.
Chen, C.
Cornelis, M.C.
Corre, T.
Coviello, A.D.
D'Adamo, P.
Davies, G.
De Faire, U.
De Geus, E.J.C.
Deary, I.J.
Dedoussis, G.V.Z.
Deloukas, P.
Ebrahim, S.
Eiriksdottir, G.
Emilsson, V.
Eriksson, J.G.
Fauser, B.C.J.M.
Ferreli, L.
Ferrucci, L.
Fischer, K.
Folsom, A.R.
Garcia, M.E.
Gasparini, P.
Gieger, C.
Glazer, N.
Grobbee, D.E.
Hall, P.
Haller, T.
Hankinson, S.E.
Hass, M.
Hayward, C.
Heath, A.C.
Hofman, A.
Ingelsson, E.
Janssens, A.C.J.W.
Johnson, A.D.
Karasik, D.
Kardia, S.L.R.
Keyzer, J.
Kiel, D.P.
Kolcic, I.
Kutalik, Z.
Lahti, J.
Lai, S.
Laisk, T.
Laven, J.S.E.
Lawlor, D.A.
Liu, J.
Lopez, L.M.
Louwers, Y.V.
Magnusson, P.K.E.
Marongiu, M.
Martin, N.G.
Klaric, I.M.
Masciullo, C.
McKnight, B.
Medland, S.E.
Melzer, D.
Mooser, V.
Navarro, P.
Newman, A.B.
Nyholt, D.R.
Onland-Moret, N.C.
Palotie, A.
Paré, G.
Parker, A.N.
Pedersen, N.L.
Peeters, P.H.M.
Pistis, G.
Plump, A.S.
Polasek, O.
Pop, V.J.M.
Psaty, B.M.
R Currency Signikkönen, K.
Rehnberg, E.
Rotter, J.I.
Rudan, I.
Sala, C.
Salumets, A.
Scuteri, A.
Singleton, A.
Smith, J.A.
Snieder, H.
Soranzo, N.
Stacey, S.N.
Starr, J.M.
Stathopoulou, M.G.
Stirrups, K.
Stolk, R.P.
Styrkarsdottir, U.
Sun, Y.V.
Tenesa, A.
Thorand, B.
Toniolo, D.
Tryggvadottir, L.
Tsui, K.
Ulivi, S.
Van Dam, R.M. 
Van Der Schouw, Y.T.
Van Gils, C.H.
Van Nierop, P.
Vink, J.M.
Visscher, P.M.
Voorhuis, M.
Waeber, G.
Wallaschofski, H.
Wichmann, H.E.
Widen, E.
Wijnands-Van Gent, C.J.M.
Willemsen, G.
Wilson, J.F.
Wolffenbuttel, B.H.R.
Wright, A.F.
Yerges-Armstrong, L.M.
Zemunik, T.
Zgaga, L.
Zillikens, M.C.
Zygmunt, M.
Arnold, A.M.
Boomsma, D.I.
Buring, J.E.
Crisponi, L.
Demerath, E.W.
Gudnason, V.
Harris, T.B.
Hu, F.B.
Hunter, D.J.
Launer, L.J.
Metspalu, A.
Montgomery, G.W.
Oostra, B.A.
Ridker, P.M.
Sanna, S.
Schlessinger, D.
Spector, T.D.
Stefansson, K.
Streeten, E.A.
Thorsteinsdottir, U.
Uda, M.
Uitterlinden, A.G.
Van Duijn, C.M.
Völzke, H.
Murray, A.
Murabito, J.M.
Visser, J.A.
Lunetta, K.L.
Issue Date: Mar-2012
Citation: Stolk, L., Perry, J.R.B., Chasman, D.I., He, C., Mangino, M., Sulem, P., Barbalic, M., Broer, L., Byrne, E.M., Ernst, F., Esko, T., Franceschini, N., Gudbjartsson, D.F., Hottenga, J.-J., Kraft, P., McArdle, P.F., Porcu, E., Shin, S.-Y., Smith, A.V., Van Wingerden, S., Zhai, G., Zhuang, W.V., Albrecht, E., Alizadeh, B.Z., Aspelund, T., Bandinelli, S., Lauc, L.B., Beckmann, J.S., Boban, M., Boerwinkle, E., Broekmans, F.J., Burri, A., Campbell, H., Chanock, S.J., Chen, C., Cornelis, M.C., Corre, T., Coviello, A.D., D'Adamo, P., Davies, G., De Faire, U., De Geus, E.J.C., Deary, I.J., Dedoussis, G.V.Z., Deloukas, P., Ebrahim, S., Eiriksdottir, G., Emilsson, V., Eriksson, J.G., Fauser, B.C.J.M., Ferreli, L., Ferrucci, L., Fischer, K., Folsom, A.R., Garcia, M.E., Gasparini, P., Gieger, C., Glazer, N., Grobbee, D.E., Hall, P., Haller, T., Hankinson, S.E., Hass, M., Hayward, C., Heath, A.C., Hofman, A., Ingelsson, E., Janssens, A.C.J.W., Johnson, A.D., Karasik, D., Kardia, S.L.R., Keyzer, J., Kiel, D.P., Kolcic, I., Kutalik, Z., Lahti, J., Lai, S., Laisk, T., Laven, J.S.E., Lawlor, D.A., Liu, J., Lopez, L.M., Louwers, Y.V., Magnusson, P.K.E., Marongiu, M., Martin, N.G., Klaric, I.M., Masciullo, C., McKnight, B., Medland, S.E., Melzer, D., Mooser, V., Navarro, P., Newman, A.B., Nyholt, D.R., Onland-Moret, N.C., Palotie, A., Paré, G., Parker, A.N., Pedersen, N.L., Peeters, P.H.M., Pistis, G., Plump, A.S., Polasek, O., Pop, V.J.M., Psaty, B.M., R Currency Signikkönen, K., Rehnberg, E., Rotter, J.I., Rudan, I., Sala, C., Salumets, A., Scuteri, A., Singleton, A., Smith, J.A., Snieder, H., Soranzo, N., Stacey, S.N., Starr, J.M., Stathopoulou, M.G., Stirrups, K., Stolk, R.P., Styrkarsdottir, U., Sun, Y.V., Tenesa, A., Thorand, B., Toniolo, D., Tryggvadottir, L., Tsui, K., Ulivi, S., Van Dam, R.M., Van Der Schouw, Y.T., Van Gils, C.H., Van Nierop, P., Vink, J.M., Visscher, P.M., Voorhuis, M., Waeber, G., Wallaschofski, H., Wichmann, H.E., Widen, E., Wijnands-Van Gent, C.J.M., Willemsen, G., Wilson, J.F., Wolffenbuttel, B.H.R., Wright, A.F., Yerges-Armstrong, L.M., Zemunik, T., Zgaga, L., Zillikens, M.C., Zygmunt, M., Arnold, A.M., Boomsma, D.I., Buring, J.E., Crisponi, L., Demerath, E.W., Gudnason, V., Harris, T.B., Hu, F.B., Hunter, D.J., Launer, L.J., Metspalu, A., Montgomery, G.W., Oostra, B.A., Ridker, P.M., Sanna, S., Schlessinger, D., Spector, T.D., Stefansson, K., Streeten, E.A., Thorsteinsdottir, U., Uda, M., Uitterlinden, A.G., Van Duijn, C.M., Völzke, H., Murray, A., Murabito, J.M., Visser, J.A., Lunetta, K.L. (2012-03). Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nature Genetics 44 (3) : 260-268. ScholarBank@NUS Repository. https://doi.org/10.1038/ng.1051
Abstract: To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22 genome-wide association studies (GWAS) in 38,968 women of European descent, with replication in up to 14,435 women. In addition to four known loci, we identified 13 loci newly associated with age at natural menopause (at P < 5 - 10 g8). Candidate genes located at these newly associated loci include genes implicated in DNA repair (EXO1, HELQ, UIMC1, FAM175A, FANCI, TLK1, POLG and PRIM1) and immune function (IL11, NLRP11 and PRRC2A (also known as BAT2)). Gene-set enrichment pathway analyses using the full GWAS data set identified exoDNase, NF-I °B signaling and mitochondrial dysfunction as biological processes related to timing of menopause. © 2012 Nature America, Inc. All rights reserved.
Source Title: Nature Genetics
URI: http://scholarbank.nus.edu.sg/handle/10635/108772
ISSN: 10614036
DOI: 10.1038/ng.1051
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