Please use this identifier to cite or link to this item: https://doi.org/10.1038/ng.2383
Title: Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
Authors: Morris, A.P.
Voight, B.F.
Teslovich, T.M.
Ferreira, T.
Segrè, A.V.
Steinthorsdottir, V.
Strawbridge, R.J.
Khan, H.
Grallert, H.
Mahajan, A.
Prokopenko, I.
Kang, H.M.
Dina, C.
Esko, T.
Fraser, R.M.
Kanoni, S.
Kumar, A.
Lagou, V.
Langenberg, C.
Luan, J.
Lindgren, C.M.
Müller-Nurasyid, M.
Pechlivanis, S.
Rayner, N.W.
Scott, L.J.
Wiltshire, S.
Yengo, L.
Kinnunen, L.
Rossin, E.J.
Raychaudhuri, S.
Johnson, A.D.
Dimas, A.S.
Loos, R.J.F.
Vedantam, S.
Chen, H.
Florez, J.C.
Fox, C.
Liu, C.-T.
Rybin, D.
Couper, D.J.
Kao, W.H.L.
Li, M.
Cornelis, M.C.
Kraft, P.
Sun, Q.
Van Dam, R.M. 
Stringham, H.M.
Chines, P.S.
Fischer, K.
Fontanillas, P.
Holmen, O.L.
Hunt, S.E.
Jackson, A.U.
Kong, A.
Lawrence, R.
Meyer, J.
Perry, J.R.B.
Platou, C.G.P.
Potter, S.
Rehnberg, E.
Robertson, N.
Sivapalaratnam, S.
Stančáková, A.
Stirrups, K.
Thorleifsson, G.
Tikkanen, E.
Wood, A.R.
Almgren, P.
Atalay, M.
Benediktsson, R.
Bonnycastle, L.L.
Burtt, N.
Carey, J.
Charpentier, G.
Crenshaw, A.T.
Doney, A.S.F.
Dorkhan, M.
Edkins, S.
Emilsson, V.
Eury, E.
Forsen, T.
Gertow, K.
Gigante, B.
Grant, G.B.
Groves, C.J.
Guiducci, C.
Herder, C.
Hreidarsson, A.B.
Hui, J.
James, A.
Jonsson, A.
Rathmann, W.
Klopp, N.
Kravic, J.
Krjutškov, K.
Langford, C.
Leander, K.
Lindholm, E.
Lobbens, S.
MäNnistö, S.
Mirza, G.
MüHleisen, T.W.
Musk, B.
Parkin, M.
Rallidis, L.
Saramies, J.
Sennblad, B.
Shah, S.
Sigursson, G.
Silveira, A.
Steinbach, G.
Thorand, B.
Trakalo, J.
Veglia, F.
Wennauer, R.
Winckler, W.
Zabaneh, D.
Campbell, H.
Van Duijn, C.
Uitterlinden, A.G.
Hofman, A.
Sijbrands, E.
Abecasis, G.R.
Owen, K.R.
Zeggini, E.
Trip, M.D.
Forouhi, N.G.
Syvänen, A.-C.
Eriksson, J.G.
Peltonen, L.
Nöthen, M.M.
Balkau, B.
Palmer, C.N.A.
Lyssenko, V.
Tuomi, T.
Isomaa, B.
Hunter, D.J.
Qi, L.
Shuldiner, A.R.
Roden, M.
Barroso, I.
Wilsgaard, T.
Beilby, J.
Hovingh, K.
Price, J.F.
Wilson, J.F.
Rauramaa, R.
Lakka, T.A.
Lind, L.
Dedoussis, G.
NjøLstad, I.
Pedersen, N.L.
Khaw, K.-T.
Wareham, N.J.
Keinanen-Kiukaanniemi, S.M.
Saaristo, T.E.
Korpi-HyöVäLti, E.
Saltevo, J.
Laakso, M.
Kuusisto, J.
Metspalu, A.
Collins, F.S.
Mohlke, K.L.
Bergman, R.N.
Tuomilehto, J.
Boehm, B.O.
Gieger, C.
Hveem, K.
Cauchi, S.
Froguel, P.
Baldassarre, D.
Tremoli, E.
Humphries, S.E.
Saleheen, D.
Danesh, J.
Ingelsson, E.
Ripatti, S.
Salomaa, V.
Erbel, R.
JöCkel, K.-H.
Moebus, S.
Peters, A.
Illig, T.
Faire, U.D.
Hamsten, A.
Morris, A.D.
Donnelly, P.J.
Frayling, T.M.
Hattersley, A.T.
Boerwinkle, E.
Melander, O.
Kathiresan, S.
Nilsson, P.M.
Deloukas, P.
Thorsteinsdottir, U.
Groop, L.C.
Stefansson, K.
Hu, F.
Pankow, J.S.
Dupuis, J.
Meigs, J.B.
Altshuler, D.
Boehnke, M.
McCarthy, M.I.
Issue Date: Sep-2012
Citation: Morris, A.P., Voight, B.F., Teslovich, T.M., Ferreira, T., Segrè, A.V., Steinthorsdottir, V., Strawbridge, R.J., Khan, H., Grallert, H., Mahajan, A., Prokopenko, I., Kang, H.M., Dina, C., Esko, T., Fraser, R.M., Kanoni, S., Kumar, A., Lagou, V., Langenberg, C., Luan, J., Lindgren, C.M., Müller-Nurasyid, M., Pechlivanis, S., Rayner, N.W., Scott, L.J., Wiltshire, S., Yengo, L., Kinnunen, L., Rossin, E.J., Raychaudhuri, S., Johnson, A.D., Dimas, A.S., Loos, R.J.F., Vedantam, S., Chen, H., Florez, J.C., Fox, C., Liu, C.-T., Rybin, D., Couper, D.J., Kao, W.H.L., Li, M., Cornelis, M.C., Kraft, P., Sun, Q., Van Dam, R.M., Stringham, H.M., Chines, P.S., Fischer, K., Fontanillas, P., Holmen, O.L., Hunt, S.E., Jackson, A.U., Kong, A., Lawrence, R., Meyer, J., Perry, J.R.B., Platou, C.G.P., Potter, S., Rehnberg, E., Robertson, N., Sivapalaratnam, S., Stančáková, A., Stirrups, K., Thorleifsson, G., Tikkanen, E., Wood, A.R., Almgren, P., Atalay, M., Benediktsson, R., Bonnycastle, L.L., Burtt, N., Carey, J., Charpentier, G., Crenshaw, A.T., Doney, A.S.F., Dorkhan, M., Edkins, S., Emilsson, V., Eury, E., Forsen, T., Gertow, K., Gigante, B., Grant, G.B., Groves, C.J., Guiducci, C., Herder, C., Hreidarsson, A.B., Hui, J., James, A., Jonsson, A., Rathmann, W., Klopp, N., Kravic, J., Krjutškov, K., Langford, C., Leander, K., Lindholm, E., Lobbens, S., MäNnistö, S., Mirza, G., MüHleisen, T.W., Musk, B., Parkin, M., Rallidis, L., Saramies, J., Sennblad, B., Shah, S., Sigursson, G., Silveira, A., Steinbach, G., Thorand, B., Trakalo, J., Veglia, F., Wennauer, R., Winckler, W., Zabaneh, D., Campbell, H., Van Duijn, C., Uitterlinden, A.G., Hofman, A., Sijbrands, E., Abecasis, G.R., Owen, K.R., Zeggini, E., Trip, M.D., Forouhi, N.G., Syvänen, A.-C., Eriksson, J.G., Peltonen, L., Nöthen, M.M., Balkau, B., Palmer, C.N.A., Lyssenko, V., Tuomi, T., Isomaa, B., Hunter, D.J., Qi, L., Shuldiner, A.R., Roden, M., Barroso, I., Wilsgaard, T., Beilby, J., Hovingh, K., Price, J.F., Wilson, J.F., Rauramaa, R., Lakka, T.A., Lind, L., Dedoussis, G., NjøLstad, I., Pedersen, N.L., Khaw, K.-T., Wareham, N.J., Keinanen-Kiukaanniemi, S.M., Saaristo, T.E., Korpi-HyöVäLti, E., Saltevo, J., Laakso, M., Kuusisto, J., Metspalu, A., Collins, F.S., Mohlke, K.L., Bergman, R.N., Tuomilehto, J., Boehm, B.O., Gieger, C., Hveem, K., Cauchi, S., Froguel, P., Baldassarre, D., Tremoli, E., Humphries, S.E., Saleheen, D., Danesh, J., Ingelsson, E., Ripatti, S., Salomaa, V., Erbel, R., JöCkel, K.-H., Moebus, S., Peters, A., Illig, T., Faire, U.D., Hamsten, A., Morris, A.D., Donnelly, P.J., Frayling, T.M., Hattersley, A.T., Boerwinkle, E., Melander, O., Kathiresan, S., Nilsson, P.M., Deloukas, P., Thorsteinsdottir, U., Groop, L.C., Stefansson, K., Hu, F., Pankow, J.S., Dupuis, J., Meigs, J.B., Altshuler, D., Boehnke, M., McCarthy, M.I. (2012-09). Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nature Genetics 44 (9) : 981-990. ScholarBank@NUS Repository. https://doi.org/10.1038/ng.2383
Abstract: To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated association. Genome-wide analyses of these data are consistent with a long tail of additional common variant loci explaining much of the variation in susceptibility to T2D. Exploration of the enlarged set of susceptibility loci implicates several processes, including CREBBP-related transcription, adipocytokine signaling and cell cycle regulation, in diabetes pathogenesis. © 2012 Nature America, Inc. All rights reserved.
Source Title: Nature Genetics
URI: http://scholarbank.nus.edu.sg/handle/10635/108768
ISSN: 10614036
DOI: 10.1038/ng.2383
Appears in Collections:Staff Publications

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