Please use this identifier to cite or link to this item: https://doi.org/10.1093/hmg/ddt205
Title: Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course
Authors: Graff, M.
Ngwa, J.S.
Workalemahu, T.
Homuth, G.
Schipf, S.
Teumer, A.
Völzke, H.
Wallaschofski, H.
Abecasis, G.R.
Edward, L.
Francesco, C.
Sanna, S.
Scheet, P.
Schlessinger, D.
Sidore, C.
Xiao, X.
Wang, Z.
Chanock, S.J.
Jacobs, K.B.
Hayes, R.B.
Hu, F.
Van Dam, R.M. 
Crout, R.J.
Marazita, M.L.
Shaffer, J.R.
Atwood, L.D.
Fox, C.S.
Heard-Costa, N.L.
White, C.
Choh, A.C.
Czerwinski, S.A.
Demerath, E.W.
Dyer, T.D.
Towne, B.
Amin, N.
Oostra, B.A.
Van Duijn, C.M.
Zillikens, M.C.
Esko, T.
Nelis, M.
Nikopensius, T.
Metspalu, A.
Strachan, D.P.
Monda, K.
Qi, L.
North, K.E.
Cupples, L.A.
Gordon-Larsen, P.
Berndt, S.I.
Issue Date: Sep-2013
Citation: Graff, M., Ngwa, J.S., Workalemahu, T., Homuth, G., Schipf, S., Teumer, A., Völzke, H., Wallaschofski, H., Abecasis, G.R., Edward, L., Francesco, C., Sanna, S., Scheet, P., Schlessinger, D., Sidore, C., Xiao, X., Wang, Z., Chanock, S.J., Jacobs, K.B., Hayes, R.B., Hu, F., Van Dam, R.M., Crout, R.J., Marazita, M.L., Shaffer, J.R., Atwood, L.D., Fox, C.S., Heard-Costa, N.L., White, C., Choh, A.C., Czerwinski, S.A., Demerath, E.W., Dyer, T.D., Towne, B., Amin, N., Oostra, B.A., Van Duijn, C.M., Zillikens, M.C., Esko, T., Nelis, M., Nikopensius, T., Metspalu, A., Strachan, D.P., Monda, K., Qi, L., North, K.E., Cupples, L.A., Gordon-Larsen, P., Berndt, S.I. (2013-09). Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course. Human Molecular Genetics 22 (17) : 3597-3607. ScholarBank@NUS Repository. https://doi.org/10.1093/hmg/ddt205
Abstract: Genetic loci forbodymassindex (BMI) in adolescenceandyoungadulthood, a period of high risk for weight gain, are understudied, yet may yield important insight into the etiology of obesity and early intervention. To identify novel genetic loci and examine the influence of known loci on BMI during this critical time period in late adolescence and early adulthood, we performed a two-stage meta-analysis using 14 genome-wide association studies in populations of European ancestry with data on BMI between ages 16 and 25 in up to 29 880 individuals. We identified seven independent loci (P < 5.0 × 10-8) near FTO (P = 3.72 × 10-23), TMEM18 (P = 3.24 × 10-17), MC4R (P = 4.41 × 10-11), TNNI3K (P = 4.32 × 10-9), SEC16B (P = 6.24 × 10-8), GNPDA2 (P = 1.11 × 10-8) and POMC (P = 4.94 × 1028) as well as a potential secondary signal at the POMC locus (rs2118404, P = 2.4 × 10-5 after conditioning on the established single-nucleotide polymorphism at this locus) in adolescents and young adults. To evaluate the impact of the established genetic loci on BMI at these young ages, we examined differences between the effect sizes of 32 published BMI loci in European adult populations (aged 18-90) and those observed in our adolescent and young adult meta-analysis. Four loci (near PRKD1, TNNI3K, SEC16B and CADM2) had larger effects and one locus (near SH2B1) had a smaller effect on BMI during adolescence and young adulthood compared with older adults (P < 0.05). These results suggest that genetic loci for BMI can vary in their effects across the life course, underlying the importance of evaluating BMI at different ages. © The Author 2013. Published by Oxford University Press. All rights reserved.
Source Title: Human Molecular Genetics
URI: http://scholarbank.nus.edu.sg/handle/10635/108760
ISSN: 09646906
DOI: 10.1093/hmg/ddt205
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.