Please use this identifier to cite or link to this item: https://doi.org/10.1210/jc.2013-2738
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dc.titleEffect of maternal glycemia on neonatal adiposity in a multiethnic asian birth cohort
dc.contributor.authorAris, I.M.
dc.contributor.authorSoh, S.E.
dc.contributor.authorTint, M.T.
dc.contributor.authorLiang, S.
dc.contributor.authorChinnadurai, A.
dc.contributor.authorSaw, S.M.
dc.contributor.authorRajadurai, V.S.
dc.contributor.authorKwek, K.
dc.contributor.authorMeaney, M.J.
dc.contributor.authorGodfrey, K.M.
dc.contributor.authorGluckman, P.D.
dc.contributor.authorYap, F.K.P.
dc.contributor.authorChong, Y.S.
dc.contributor.authorLee, Y.-S.
dc.date.accessioned2014-11-26T02:12:19Z
dc.date.available2014-11-26T02:12:19Z
dc.date.issued2014-01
dc.identifier.citationAris, I.M., Soh, S.E., Tint, M.T., Liang, S., Chinnadurai, A., Saw, S.M., Rajadurai, V.S., Kwek, K., Meaney, M.J., Godfrey, K.M., Gluckman, P.D., Yap, F.K.P., Chong, Y.S., Lee, Y.-S. (2014-01). Effect of maternal glycemia on neonatal adiposity in a multiethnic asian birth cohort. Journal of Clinical Endocrinology and Metabolism 99 (1) : 240-247. ScholarBank@NUS Repository. https://doi.org/10.1210/jc.2013-2738
dc.identifier.issn0021972X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/108746
dc.description.abstractContext: Gestational hyperglycemia increases the risk of obesity and diabetes in offspring later in life. Objective: We examined the relationship between gestational glycemia and neonatal adiposity in a multiethnic cohort of Singaporean neonates. Design: A prospective mother-offspring cohort study recruited 1247 pregnant mothers (57.2% Chinese, 25.5% Malay, 17.3% Indian) and performed 75-g, 2-hour oral glucose tolerance tests at 26-28 weeks' gestation; glucose levels were available for 1081 participants. Neonatal anthropometry (birth weight, length, triceps, and subscapular skinfolds) was measured, and percentage body fat (%BF) was derived using our published equation. Associations of maternal glucose with excessive neonatal adiposity [large for gestational age; %BF; and sum of skinfolds (∑SFT) > 90th centile] were assessed using multiple logistic regression analyses. Results: Adjusting for potential confounders we observed strong positive continuous associations across the range of maternal fasting and 2-hour glucose in relation to excessive neonatal adiposity; each 1 SD increase in fasting glucose was associated with 1.31 [95% confidence interval (CI) 1.10-1.55], 1.72 (95% CI 1.31-2.27) and 1.64 (95% CI 1.32-2.03) increases in odds ratios for large for gestational age and %BF and ∑SFT greater than the 90th centile, respectively. Corresponding odds ratios for 2-hour glucose were 1.11 (95% CI 0.92-1.33), 1.55 (95% CI 1.10-2.20), and 1.40 (95% CI 1.10-1.79), respectively. The influence of high maternal fasting glucose on neonatal ∑SFT was less pronounced in Indians compared with Chinese (interaction P = .005). Conclusions: A continuous relationship between maternal glycemia and excessive neonatal adiposity extends across the range of maternal glycemia. Compared with Chinese infants, Indian infants may be less susceptible to excessive adiposity from high maternal glucose levels. (J Clin Endocrinol Metab 99: 240-247, 2014). © Copyright 2014 by The Endocrine Society.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1210/jc.2013-2738
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.description.doi10.1210/jc.2013-2738
dc.description.sourcetitleJournal of Clinical Endocrinology and Metabolism
dc.description.volume99
dc.description.issue1
dc.description.page240-247
dc.description.codenJCEMA
dc.identifier.isiut000333402200060
dc.description.seriesGUSTO (Growing up towards Healthy Outcomes)
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