Please use this identifier to cite or link to this item: https://doi.org/10.4161/auto.23965
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dc.titleDual suppressive effect of MTORC1 on autophagy: Tame the dragon by shackling both the head and the tail
dc.contributor.authorZhou, J.
dc.contributor.authorTan, S.-H.
dc.contributor.authorCodogno, P.
dc.contributor.authorShen, H.-M.
dc.date.accessioned2014-11-26T02:12:18Z
dc.date.available2014-11-26T02:12:18Z
dc.date.issued2013-05
dc.identifier.citationZhou, J., Tan, S.-H., Codogno, P., Shen, H.-M. (2013-05). Dual suppressive effect of MTORC1 on autophagy: Tame the dragon by shackling both the head and the tail. Autophagy 9 (5) : 803-805. ScholarBank@NUS Repository. https://doi.org/10.4161/auto.23965
dc.identifier.issn15548627
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/108744
dc.description.abstractThe lysosome is a key subcellular organelle that receives and degrades macromolecules from endocytic, secretory and autophagic pathways. Lysosomal function is thus critical for an efficient autophagic process. However, the molecular mechanisms mediating lysosomal function upon autophagic induction are largely unknown. Our laboratory recently discovered that upon autophagy activation, the lysosome is activated, and this functional activation is dependent on MTORC1 suppression, suggesting that MTORC1 exerts a suppressive effect on lysosomal function. Therefore, data from our study demonstrate that MTORC1 exerts a dual inhibitory effect on autophagy, blocking autophagy not only at the initiation stage via suppression of the ULK1 complex, but also at the degradation stage via inhibition of lysosomal function. We think that understanding the negative regulatory effect of MTORC1 on lysosomal function expands the functional scope of MTORC1 in autophagy regulation, and offers new clues for developing novel interventional strategies in autophagyand lysosome-related diseases. © 2013 Landes Bioscience.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.4161/auto.23965
dc.sourceScopus
dc.subjectAutophagosome
dc.subjectAutophagy
dc.subjectFusion
dc.subjectLysosome
dc.subjectMTORC1
dc.typeArticle
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.description.doi10.4161/auto.23965
dc.description.sourcetitleAutophagy
dc.description.volume9
dc.description.issue5
dc.description.page803-805
dc.identifier.isiut000323174100023
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