Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bbapap.2013.01.030
Title: Sieving through the cancer secretome
Authors: Lin, Q.
Tan, H.T. 
Lim, H.S.R.
Chung, M.C.M.
Keywords: Biomarker
Cancer
Proteomics
Secreted protein
Secretome
Issue Date: 2013
Citation: Lin, Q., Tan, H.T., Lim, H.S.R., Chung, M.C.M. (2013). Sieving through the cancer secretome. Biochimica et Biophysica Acta - Proteins and Proteomics 1834 (11) : 2360-2371. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbapap.2013.01.030
Abstract: Cancer is among the most prevalent and serious health problems worldwide. Therefore, there is an urgent need for novel cancer biomarkers with high sensitivity and specificity for early detection and management of the disease. The cancer secretome, encompassing all the proteins that are secreted by cancer cells, is a promising source of biomarkers as the secreted proteins are most likely to enter the blood circulation. Moreover, since secreted proteins are responsible for signaling and communication with the tumor microenvironment, studying the cancer secretome would further the understanding of cancer biology. Latest developments in proteomics technologies have significantly advanced the study of the cancer secretome. In this review, we will present an overview of the secretome sample preparation process and summarize the data from recent secretome studies of six common cancers with high mortality (breast, colorectal, gastric, liver, lung and prostate cancers). In particular, we will focus on the various platforms that were employed and discuss the clinical applicability of the key findings in these studies. This article is part of a Special Issue entitled: An Updated Secretome. © 2013 Elsevier B.V.
Source Title: Biochimica et Biophysica Acta - Proteins and Proteomics
URI: http://scholarbank.nus.edu.sg/handle/10635/108689
ISSN: 15709639
DOI: 10.1016/j.bbapap.2013.01.030
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

20
checked on Oct 18, 2019

WEB OF SCIENCETM
Citations

20
checked on Oct 11, 2019

Page view(s)

44
checked on Oct 11, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.