Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bbcan.2012.05.006
Title: Regulators of mammalian Hippo pathway in cancer
Authors: Liu, A.M. 
Wong, K.-F. 
Jiang, X.
Qiao, Y.
Luk, J.M.
Keywords: Hippo signaling
LATS1/2
MST1/2
Regulators
Solid cancer
YAP
Issue Date: Dec-2012
Citation: Liu, A.M., Wong, K.-F., Jiang, X., Qiao, Y., Luk, J.M. (2012-12). Regulators of mammalian Hippo pathway in cancer. Biochimica et Biophysica Acta - Reviews on Cancer 1826 (2) : 357-364. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbcan.2012.05.006
Abstract: Hippo pathway, originally discovered in Drosophila, is responsible for organ size control. The pathway is conserved in mammals and has a significant role in restraining cancer development. Regulating the Hippo pathway thus represents a potential therapeutic approach to treat cancer, which however requires deep understanding of the targeted pathway. Despite our limited knowledge on the pathway, there are increasing discoveries of new molecules that regulate and modulate the Hippo downstream signaling particularly in various solid malignancies, from extracellular stimuli or via pathway crosstalk. Herein, we discuss the roles of newly identified and key regulators that connect with core components (MST1/2, LATS1/2, SAV1, and MOB1) and downstream effector (YAP) in the Hippo pathway having an important role in cancer development and progression. Understanding of the mammalian Hippo pathway regulation may shed new insights to allow us selecting the right oncogenic targets and designing effective drugs for cancer treatments. © 2012 Elsevier B.V.
Source Title: Biochimica et Biophysica Acta - Reviews on Cancer
URI: http://scholarbank.nus.edu.sg/handle/10635/108683
ISSN: 0304419X
DOI: 10.1016/j.bbcan.2012.05.006
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

41
checked on Jan 24, 2020

WEB OF SCIENCETM
Citations

39
checked on Jan 24, 2020

Page view(s)

81
checked on Jan 25, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.