Please use this identifier to cite or link to this item: https://doi.org/10.1042/BC20100150
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dc.titleRabs and other small GTPases in ciliary transport
dc.contributor.authorLim, Y.S.
dc.contributor.authorEn Lin Chua, C.
dc.contributor.authorTang, B.L.
dc.date.accessioned2014-11-25T09:48:58Z
dc.date.available2014-11-25T09:48:58Z
dc.date.issued2011-05
dc.identifier.citationLim, Y.S., En Lin Chua, C., Tang, B.L. (2011-05). Rabs and other small GTPases in ciliary transport. Biology of the Cell 103 (5) : 209-221. ScholarBank@NUS Repository. https://doi.org/10.1042/BC20100150
dc.identifier.issn02484900
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/108680
dc.description.abstractThe non-motile primary cilium is a single, microtubule-based hair-like projection that emanates from most, if not all, non-dividing mammalian cells. Enriched in a variety of signalling receptors and accessories, the cilium mediates crucial sensory and regulatory functions during development and postnatal tissue homoeostasis. Maintenance of ciliary morphology and function requires continuous IFT (intraflagellar transport), and recent findings have shed light on some molecular details of how ciliogenesis is dependent on targeted exocytic membrane trafficking from the Golgi. The ARL [Arf (ADP ribosylation factor)-related] small GTPase Arf4 functions in TGN (trans-Golgi network) sorting of cilia-targeted rhodopsin into carrier vesicles, while Arl6 (Arf-like 6) and Arl13b regulate aspects of ciliary transport and IFT. Ciliogenesis and ciliary functions are also regulated by small Rabs. Rab8a, in conjunction with Rab11a, and via its interaction with a multitude of proteins associated with the ciliary basal body and axoneme/membrane, appears to be critical for ciliogenesis. Rab8's close homologue Rab10 may also play a ciliogenic role in some cells. Rab23, the depletion or inactivation of which affects cilia formation, may regulate specific ciliary protein targeting and turnover, particularly those involved in Shh (Sonic hedgehog) signalling. Recent findings have also implicated Ran, a small GTPase better known for nuclear import, in ciliary targeting of the KIF17 motor protein. We highlight and discuss recent findings on how Rabs and other small GTPases mediate ciliogenesis and ciliary traffic. © The Authors Journal compilation © 2011 Portland Press Limited.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1042/BC20100150
dc.sourceScopus
dc.subjectCilia
dc.subjectIntraflagellar transport (IFT)
dc.subjectRab
dc.subjectSonic hedgehog signalling
dc.typeReview
dc.contributor.departmentBIOCHEMISTRY
dc.description.doi10.1042/BC20100150
dc.description.sourcetitleBiology of the Cell
dc.description.volume103
dc.description.issue5
dc.description.page209-221
dc.description.codenBCELD
dc.identifier.isiut000292430900001
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