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Title: Phosphoproteomics, oncogenic signaling and cancer research
Authors: Chong, P.-K. 
Lee, H. 
Kong, J.W.-F.
Loh, M.C.-S.
Wong, C.-H.
Lim, Y.-P. 
Keywords: Cancer
Epidermal growth factor receptor
Tyrosine kinase
Issue Date: Nov-2008
Citation: Chong, P.-K., Lee, H., Kong, J.W.-F., Loh, M.C.-S., Wong, C.-H., Lim, Y.-P. (2008-11). Phosphoproteomics, oncogenic signaling and cancer research. Proteomics 8 (21) : 4370-4382. ScholarBank@NUS Repository.
Abstract: The past 5 years have seen an explosion of phosphoproteomics methods development. In this review, using epidermal growth-factor signaling as a model, we will discuss how phosphoproteomics, along with bioinformatics and computational modeling, have impacted key aspects of oncogenic signaling such as in the temporal fine mapping of phosphorylation events, and the identification of novel tyrosine kinase substrates and phosphorylation sites. We submit that the next decade will see considerable exploitation of phosphoproteomics in cancer research. Such a phenomenon is already happening as exemplified by its use in promoting the understanding of the molecular etiology of cancer and target-directed therapeutics. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
Source Title: Proteomics
ISSN: 16159853
DOI: 10.1002/pmic.200800051
Appears in Collections:Staff Publications

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