Please use this identifier to cite or link to this item:
Title: Meta- and pooled analysis of GSTT1 and lung cancer: A HuGE-GSEC review
Authors: Raimondi, S.
Paracchini, V.
Autrup, H.
Barros-Dios, J.M.
Benhamou, S.
Boffetta, P.
Cote, M.L.
Dialyna, I.A.
Dolzan, V.
Filiberti, R.
Garte, S.
Hirvonen, A.
Husgafvel-Pursiainen, K.
Imyanitov, E.N.
Kalina, I.
Kang, D.
Kiyohara, C.
Kohno, T.
Kremers, P.
Lan, Q.
London, S.
Povey, A.C.
Rannug, A.
Reszka, E.
Risch, A.
Romkes, M.
Schneider, J.
Seow, A. 
Shields, P.G.
Sobti, R.C.
Sørensen, M.
Spinola, M.
Spitz, M.R.
Strange, R.C.
Stücker, I.
Sugimura, H.
To-Figueras, J.
Tokudome, S.
Yang, P.
Yuan, J.-M.
Warholm, M.
Taioli, E.
Keywords: Disease susceptibility
Genetic predisposition to disease
Lung neoplasms
Issue Date: Dec-2006
Citation: Raimondi, S., Paracchini, V., Autrup, H., Barros-Dios, J.M., Benhamou, S., Boffetta, P., Cote, M.L., Dialyna, I.A., Dolzan, V., Filiberti, R., Garte, S., Hirvonen, A., Husgafvel-Pursiainen, K., Imyanitov, E.N., Kalina, I., Kang, D., Kiyohara, C., Kohno, T., Kremers, P., Lan, Q., London, S., Povey, A.C., Rannug, A., Reszka, E., Risch, A., Romkes, M., Schneider, J., Seow, A., Shields, P.G., Sobti, R.C., Sørensen, M., Spinola, M., Spitz, M.R., Strange, R.C., Stücker, I., Sugimura, H., To-Figueras, J., Tokudome, S., Yang, P., Yuan, J.-M., Warholm, M., Taioli, E. (2006-12). Meta- and pooled analysis of GSTT1 and lung cancer: A HuGE-GSEC review. American Journal of Epidemiology 164 (11) : 1027-1042. ScholarBank@NUS Repository.
Abstract: Lung cancer is the most common malignancy in the Western world, and the main risk factor is tobacco smoking. Polymorphisms in metabolic genes may modulate the risk associated with environmental factors. The glutathione S-transferase theta 1 gene (GSTT1) is a particularly attractive candidate for lung cancer susceptibility because of its involvement in the metabolism of polycyclic aromatic hydrocarbons found in tobacco smoke and of other chemicals, pesticides, and industrial solvents. The frequency of the GSTT1 null genotype is lower among Caucasians (10-20%) than among Asians (50-60%). The authors present a meta- and a pooled analysis of case-control, genotype-based studies that examined the association between GSTT1 and lung cancer (34 studies, 7,629 cases and 10,087 controls for the meta-analysis; 34 studies, 7,044 cases and 10,000 controls for the pooled analysis). No association was observed between GSTT1 deletion and lung cancer for Caucasians (odds ratio (OR) = 0.99, 95% confidence interval (CI): 0.87, 1.12); for Asians, a positive association was found (OR = 1.28, 95% CI: 1.10, 1.49). In the pooled analysis, the odds ratios were not significant for either Asians (OR = 0.97, 95% CI: 0.83, 1.13) or Caucasians (OR = 1.09, 95% CI: 0.99, 1.21). No significant interaction was observed between GSTT1 and smoking on lung cancer, whereas GSTT1 appeared to modulate occupational-related lung cancer. Copyright © 2006 by the Johns Hopkins Bloomberg School of Public Health All rights reserved.
Source Title: American Journal of Epidemiology
ISSN: 00029262
DOI: 10.1093/aje/kwj321
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Aug 4, 2021


checked on Aug 4, 2021

Page view(s)

checked on Aug 1, 2021

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.