Please use this identifier to cite or link to this item:
|Title:||Angiomotin'g YAP into the nucleus for cell proliferation and cancer development||Authors:||Hong, W.||Issue Date:||3-Sep-2013||Citation:||Hong, W. (2013-09-03). Angiomotin'g YAP into the nucleus for cell proliferation and cancer development. Science Signaling 6 (291) : -. ScholarBank@NUS Repository. https://doi.org/10.1126/scisignal.2004573||Abstract:||The Hippo pathway regulates cell proliferation and apoptosis during development, tissue regeneration, and carcinogenesis. Nuclear translocation of the transcription factors Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) and their subsequent interaction with TEA domain (TEAD) transcriptional factors program pro-proliferative and antiapoptotic transcription. Scaffold proteins angiomotin (Amot) and angiomotin-related AmotL1 and AmotL2 were recently identifi ed as negative regulators of YAP and TAZ by preventing their nuclear translocation. In this issue of Science Signaling, Yi et al. show that Amot may also promote nuclear translocation of YAP and act as a transcriptional cofactor of the YAP-TEAD complex to facilitate proliferation of biliary epithelial cells and cancer development of the liver either in response to tissue injury or in the absence of the tumor suppressor Merlin. These seemingly controversial results highlight that our understanding of Amot proteins in the Hippo pathway is so far limited. Copyright © 2008 by the American Association for the Advancement of Science.||Source Title:||Science Signaling||URI:||http://scholarbank.nus.edu.sg/handle/10635/108651||ISSN:||19450877||DOI:||10.1126/scisignal.2004573|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jul 22, 2021
WEB OF SCIENCETM
checked on Jul 14, 2021
checked on Jul 13, 2021
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.