Please use this identifier to cite or link to this item: https://doi.org/10.1002/jcp.22286
Title: Syntaxin 16: Unraveling cellular physiology through a ubiquitous SNARE molecule
Authors: Chen, Y.
Gan, B.Q.
Tang, B.L. 
Issue Date: Nov-2010
Citation: Chen, Y., Gan, B.Q., Tang, B.L. (2010-11). Syntaxin 16: Unraveling cellular physiology through a ubiquitous SNARE molecule. Journal of Cellular Physiology 225 (2) : 326-332. ScholarBank@NUS Repository. https://doi.org/10.1002/jcp.22286
Abstract: Syntaxin 16 (Syx16) is member of the soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) family of molecules that functions in membrane fusion in eukaryotic cells. A rather ubiquitously expressed, tail-anchored membrane protein localized mainly at the trans-Golgi network (TGN), it mediates primarily retrograde endosomal-TGN transport. In spite of its ubiquitous expression, Syx16 has specific and interesting roles in the physiology of specialized cells, including Glut4 dynamics, dendritic outgrowth-related membrane traffic, and cytokinesis. We discussed these physiological functions of Syx16 in the light of what is known of its subcellular localization, vesicular trafficking pathways involved, cognate SNARE partners and other interacting proteins. Further, we speculate on some possible pathophysiological roles of Syx16. © 2010 Wiley-Liss, Inc.
Source Title: Journal of Cellular Physiology
URI: http://scholarbank.nus.edu.sg/handle/10635/108645
ISSN: 00219541
DOI: 10.1002/jcp.22286
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