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|dc.title||Total or partial knee replacement? Cost-utility analysis in patients with knee osteoarthritis based on a 2-year observational study|
|dc.identifier.citation||Xie, F., Lo, N.-N., Tarride, J.-E., O'Reilly, D., Goeree, R., Lee, H.-P. (2010-02). Total or partial knee replacement? Cost-utility analysis in patients with knee osteoarthritis based on a 2-year observational study. European Journal of Health Economics 11 (1) : 27-34. ScholarBank@NUS Repository. https://doi.org/10.1007/s10198-009-0154-5|
|dc.description.abstract||The objective of this study was to evaluate incremental cost-utility of total knee replacement (TKR) versus unicompartmental knee arthroplasty (UKA) in patients with knee osteoarthritis (OA) of the medial compartment. A 2-year non-randomised prospective observational cohort study was conducted in unicompartmental knee osteoarthritis patients scheduled for TKR (n = 431) or UKA (n = 102). Costs were identified using administrative databases and health outcomes were measured using the SF-36 and the Oxford knee score (OKS) 1 week before, 6 months after, and 2 years after surgery. The incremental cost-utility ratio (ICUR) for TKR versus UKA was calculated and its 95% confidence interval estimated using a nonparametric bootstrapping technique. Cost-effectiveness acceptability curves were constructed from different perspectives. On average, from the societal perspective, the ICUR was US 65,245 per quality-adjusted life-year (QALY). In the scenario with costs calculated from the perspective of patients, the ICUR was 60,382/QALY. This value decreased to 4,860/QALY in the scenario with costs calculated from the governmental perspective. However, the 95% confidence interval of ICURs cannot be defined because more than 5% bootstrapped samples fell into the upper left quadrant of the cost-effectiveness plane from all three perspectives. Based on the 2-year data, TKR gained more QALYs at higher costs compared to UKA. A long-term prospective study is necessary to determine cost-effectiveness of TKR and UKA. © 2009 Springer-Verlag.|
|dc.contributor.department||EPIDEMIOLOGY & PUBLIC HEALTH|
|dc.description.sourcetitle||European Journal of Health Economics|
|Appears in Collections:||Staff Publications|
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