Please use this identifier to cite or link to this item:
|Title:||Structural and functional similarity between the Vgll1-TEAD and the YAP-TEAD complexes||Authors:||Pobbati, A.V.
|Issue Date:||3-Jul-2012||Citation:||Pobbati, A.V., Chan, S.W., Lee, I., Song, H., Hong, W. (2012-07-03). Structural and functional similarity between the Vgll1-TEAD and the YAP-TEAD complexes. Structure 20 (7) : 1135-1140. ScholarBank@NUS Repository. https://doi.org/10.1016/j.str.2012.04.004||Abstract:||The structure of the complex between the transcription cofactor Vgll1 and the transcription factor TEAD4, the mammalian equivalent of the Drosophila Vestigial and Scalloped, respectively, is determined in this study. Remarkably, Vgll1 interacts with TEAD in a manner similar to the transcription coactivators, as well as oncogenes YAP and TAZ, despite having a varied primary sequence. Vgll1-TEAD complex upregulates the expression of IGFBP-5, a proliferation- promoting gene, and facilitates anchorage-independent cell proliferation. The YAP/TAZ-TEAD complex also upregulates several other proliferation-promoting genes and also promotes anchorage-independent cell proliferation. Given its structural and functional similarity to YAP/TAZ, Vgll1 has the potential to promote cancer progression. © 2012 Elsevier Ltd.||Source Title:||Structure||URI:||http://scholarbank.nus.edu.sg/handle/10635/108555||ISSN:||09692126||DOI:||10.1016/j.str.2012.04.004|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.