Please use this identifier to cite or link to this item: https://doi.org/10.1007/s00018-011-0887-z
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dc.titleSNX3-dependent regulation of epidermal growth factor receptor (EGFR) trafficking and degradation by aspirin in epidermoid carcinoma (A-431) cells
dc.contributor.authorChiow, K.H.
dc.contributor.authorTan, Y.
dc.contributor.authorChua, R.Y.
dc.contributor.authorHuang, D.
dc.contributor.authorNg, M.L.M.
dc.contributor.authorTorta, F.
dc.contributor.authorWenk, M.R.
dc.contributor.authorWong, S.H.
dc.date.accessioned2014-11-25T09:47:29Z
dc.date.available2014-11-25T09:47:29Z
dc.date.issued2012-05
dc.identifier.citationChiow, K.H., Tan, Y., Chua, R.Y., Huang, D., Ng, M.L.M., Torta, F., Wenk, M.R., Wong, S.H. (2012-05). SNX3-dependent regulation of epidermal growth factor receptor (EGFR) trafficking and degradation by aspirin in epidermoid carcinoma (A-431) cells. Cellular and Molecular Life Sciences 69 (9) : 1505-1521. ScholarBank@NUS Repository. https://doi.org/10.1007/s00018-011-0887-z
dc.identifier.issn1420682X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/108551
dc.description.abstractSince being introduced globally as aspirin in 1899, acetylsalicylic acid has been widely used as an analgesic, anti-inflammation, anti-pyretic, and anti-thrombotic drug for years. Aspirin had been reported to downregulate surface expression of CD40, CD80, CD86, and MHCII in myeloid dendritic cells (DC), which played essential roles in regulating the immune system. We hypothesized that the down-regulation of these surface membrane proteins is partly due to the ability of aspirin in regulating trafficking/sorting of endocytosed surface membrane proteins. By using an established epidermoid carcinoma cell line (A-431), which overexpresses the epidermal growth factor receptor (EGFR) and transferrin receptor (TfnR), we show that aspirin (1) reduces cell surface expression of EGFR and (2) accumulates endocytosed- EGFR and -TfnR in the early/sorting endosome (ESE). Further elucidation of the mechanism suggests that aspirin enhances recruitment of SNX3 and SNX5 to membranes and consistently, both SNX3 and SNX5 play essential roles in the aspirin-mediated accumulation of endocytosed-TfnR at the ESE. This study sheds light on how aspirin may down-regulate surface expression of EGFR by inhibiting/delaying the exit of endocytosed- EGFR from the ESE and recycling of endocytosed-EGFR back to the cell surface. © 2011 Springer Basel AG.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1007/s00018-011-0887-z
dc.sourceScopus
dc.subjectAspirin
dc.subjectEndocytosis
dc.subjectEpidermal growth factor receptor
dc.subjectReceptor trafficking
dc.subjectSorting nexins
dc.subjectTransferrin receptor
dc.typeArticle
dc.contributor.departmentMECHANOBIOLOGY INSTITUTE
dc.contributor.departmentMICROBIOLOGY
dc.description.doi10.1007/s00018-011-0887-z
dc.description.sourcetitleCellular and Molecular Life Sciences
dc.description.volume69
dc.description.issue9
dc.description.page1505-1521
dc.description.codenCMLSF
dc.identifier.isiut000303408800008
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