Please use this identifier to cite or link to this item:
Title: Second primary cancers in patients with nasopharyngeal carcinoma: A pooled analysis of 13 cancer registries
Authors: Scélo, G.
Boffetta, P.
Corbex, M.
Chia, K.-S. 
Hemminki, K.
Friis, S.
Pukkala, E.
Weiderpass, E.
McBride, M.L.
Tracey, E.
Brewster, D.H.
Pompe-Kirn, V.
Kliewer, E.V.
Tonita, J.M.
Martos, C.
Jonasson, J.G.
Brennan, P.
Keywords: Cancer registry
Nasopharyngeal carcinoma
Second primary cancers
Issue Date: Apr-2007
Citation: Scélo, G., Boffetta, P., Corbex, M., Chia, K.-S., Hemminki, K., Friis, S., Pukkala, E., Weiderpass, E., McBride, M.L., Tracey, E., Brewster, D.H., Pompe-Kirn, V., Kliewer, E.V., Tonita, J.M., Martos, C., Jonasson, J.G., Brennan, P. (2007-04). Second primary cancers in patients with nasopharyngeal carcinoma: A pooled analysis of 13 cancer registries. Cancer Causes and Control 18 (3) : 269-278. ScholarBank@NUS Repository.
Abstract: Objective: To study the risk of second primary cancers in nasopharyngeal carcinoma (NPC) patients and the risk of NPC as second primary cancer. Methods: We used data from the cancer registries from Singapore and from 12 low-incidence areas, including a total of 8,947 first occurring NPC cases, and 167 second occurring cases. We calculated standardized incidence ratios (SIRs) by comparing the second cancer incidence in NPC patients to the first primary cancer incidence in non-cancer population. We also calculated SIRs of second NPC after other primaries. Results: In Singapore, the risk of cancers of the lung (SIR = 0.42), stomach (SIR = 0.41), and colon (SIR = 0.23) was significantly decreased after NPC, whereas that of cancer of the tongue (SIR = 11.1) was significantly increased. In Australia, Canada, and Europe, the risk of non-Hodgkin's lymphoma (NHL) (SIR = 3.06), tongue cancer (SIR = 5.29), brain cancer (SIR = 3.89), myeloid leukemia (SIR = 3.85), and non-melanoma skin cancer (NMSC) (SIR = 3.47) was significantly increased after NPC. Incidences of second occurring NPCs following various primary cancers were not significantly altered compared to the incidence of first occurring NPCs. Conclusions: Immune suppression (NHL, NMSC), shared genetic factors (lung cancer, NHL, myeloid leukemia), and shared environmental risk factors (tongue and brain cancers) might explain the associations. Except for NHL, there was no evidence of association with other Epstein-Barr virus-related cancers. © 2007 Springer Science+Business Media B.V.
Source Title: Cancer Causes and Control
ISSN: 09575243
DOI: 10.1007/s10552-006-0101-z
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Jan 24, 2020


checked on Jan 16, 2020

Page view(s)

checked on Jan 25, 2020

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.