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Title: Retinal vascular geometry in Asian persons with diabetes and retinopathy
Authors: Cheung, C.Y.-L. 
Lamoureux, E.
Ikram, K.
Sasongko, M.B.
Ding, J.
Zheng, Y.
Mitchell, P.
Wang, J.J.
Wong, T.Y. 
Keywords: Diabetes
Issue Date: 2012
Citation: Cheung, C.Y.-L.,Lamoureux, E.,Ikram, K.,Sasongko, M.B.,Ding, J.,Zheng, Y.,Mitchell, P.,Wang, J.J.,Wong, T.Y. (2012). Retinal vascular geometry in Asian persons with diabetes and retinopathy. Journal of Diabetes Science and Technology 6 (3) : 595-605. ScholarBank@NUS Repository.
Abstract: Purpose: Our purpose was to examine the relationship of retinal vascular parameters with diabetes and retinopathy in an older Asian population. Methods: Retinal photographs from participants of a population-based survey of Asian Malay persons aged 40-80 years were analyzed. Specific retinal vascular parameters (tortuosity, branching angle, fractal dimension, and caliber) were measured using a semiautomated computer-based program. Diabetes was defined as random plasma glucose ≥ 11.1 mmol/liter, the use of diabetes medication, or physician-diagnosed diabetes. Retinopathy signs were graded from photographs using the modified Airlie House classification system. Results: A total of 2735 persons were included in the study. Persons with diabetes (n = 594) were more likely to have straighter (less tortuous) arterioles and wider arteriolar and venular caliber than those without diabetes (n = 2141). Among subjects with diabetes, those with retinopathy had wider venular caliber than those without retinopathy (211.3 versus 204.9 μm, p = .001). Among nondiabetic subjects, however, those with retinopathy had more tortuous venules than those without retinopathy [5.19(×104) versus 4.27(×104), p < .001]. Conclusions: Retinal vascular parameters varied by diabetes and retinopathy status in this older Asian cohort. Our findings suggest that subtle alterations in retinal vascular architecture are influenced by diabetes. © Diabetes Technology Society.
Source Title: Journal of Diabetes Science and Technology
ISSN: 19322968
DOI: 10.1177/193229681200600315
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