Please use this identifier to cite or link to this item: https://doi.org/10.1002/cbf.2827
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dc.titleRab GTPases regulating receptor trafficking at the late endosome-lysosome membranes
dc.contributor.authorNg, E.L.
dc.contributor.authorGan, B.Q.
dc.contributor.authorNg, F.
dc.contributor.authorTang, B.L.
dc.date.accessioned2014-11-25T09:46:57Z
dc.date.available2014-11-25T09:46:57Z
dc.date.issued2012-08
dc.identifier.citationNg, E.L., Gan, B.Q., Ng, F., Tang, B.L. (2012-08). Rab GTPases regulating receptor trafficking at the late endosome-lysosome membranes. Cell Biochemistry and Function 30 (6) : 515-523. ScholarBank@NUS Repository. https://doi.org/10.1002/cbf.2827
dc.identifier.issn02636484
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/108506
dc.description.abstractLysosomes serve key degradative functions for the turnover of membrane lipids and protein components. Its biogenesis is principally dependent on exocytic traffic from the late endosome via the trans-Golgi network, and it also receives cargo to be degraded from the endocytic pathway. Membrane trafficking to the late endosome-lysosome is tightly regulated to maintain the amplitude of signalling events and cellular homeostasis. Key coordinators of lysosomal traffic include members of the Rab small GTPase family. Amongst these, Rab7, Rab9 and the more recently studied Rab22B/31 have all been reported to regulate membrane trafficking processed at the late endosome-lysosome system. We discuss what is known about the roles of these Rab proteins and their interacting partners on the regulation of traffic of important receptor proteins such as the epidermal growth factor receptor (EGFR) and the mannose 6-phosphate receptor (M6PR), in association with the late endosome-lysosome system. Better knowledge of EGFR and M6PR traffic in this regard may aid in understanding the pathological processes, such as oncogenic transformations associated with these receptors. © 2012 John Wiley & Sons, Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/cbf.2827
dc.sourceScopus
dc.subjectEpidermal growth factor receptor (EGFR)
dc.subjectLate endosome/multi-vesicular body (MVB)
dc.subjectLysosome
dc.subjectMannose 6-phosphate receptor (M6PR)
dc.subjectRab GTPase
dc.subjectTrans-Golgi network (TGN)
dc.typeArticle
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.contributor.departmentBIOCHEMISTRY
dc.description.doi10.1002/cbf.2827
dc.description.sourcetitleCell Biochemistry and Function
dc.description.volume30
dc.description.issue6
dc.description.page515-523
dc.description.codenCBFUD
dc.identifier.isiut000307787200012
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