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Title: Multivoxel MR spectroscopic imaging - Distinguishing intracranial tumours from non-neoplastic disease
Authors: Nagar, V.A.
Ye, J.
Xu, M.
Ng, W.-H.
Yeo, T.-T.
Ong, P.-L.
Lim, C.C.T. 
Keywords: Brain neoplasm
Magnetic resonance imaging
Nuclear magnetic resonance
Issue Date: May-2007
Citation: Nagar, V.A.,Ye, J.,Xu, M.,Ng, W.-H.,Yeo, T.-T.,Ong, P.-L.,Lim, C.C.T. (2007-05). Multivoxel MR spectroscopic imaging - Distinguishing intracranial tumours from non-neoplastic disease. Annals of the Academy of Medicine Singapore 36 (5) : 309-313. ScholarBank@NUS Repository.
Abstract: Introduction: Multi-voxel MR spectroscopic imaging (MRSI) provides chemical metabolite information that can supplement conventional MR imaging in the study of intracranial neoplasia. Our purpose was to use a robust semi-automated spectroscopic analysis to distinguish intracranial tumours from non-neoplastic disease. Materials and Methods: Twenty intracranial tumours and 15 patients with non-neoplastic disease confirmed on histological examination or serial neuroimaging were studied with 2-dimensional MRSI using point-resolved spectroscopic (PRESS) imaging localisation. Using semi-automated post-processing software, spectra were analysed for peak heights of choline (Cho), creatine (Cr), N-acetyl aspartate (NAA), lactate (Lac) and lipid (Lip). Normalised Cho (nCho) ratios, computed by dividing maximum Cho in the lesion by the normal-appearing brain, were compared between intracranial tumours and non-neoplastic disease. Results: Meningiomas displayed homogenously elevated Cho. Malignant tumours, especially large glioblastoma multiforme, displayed inhomogeneity of metabolites within the tumour. All tumours had elevation of nCho >1 (mean 1.91 ± 0.65), and non-neoplastic diseases had tumour nCho
Source Title: Annals of the Academy of Medicine Singapore
ISSN: 03044602
Appears in Collections:Staff Publications

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