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Title: Linking membrane dynamics and trafficking to autophagy and the unfolded protein response
Authors: Chua, C.E.L.
Tang, B.L. 
Issue Date: Aug-2013
Citation: Chua, C.E.L., Tang, B.L. (2013-08). Linking membrane dynamics and trafficking to autophagy and the unfolded protein response. Journal of Cellular Physiology 228 (8) : 1638-1640. ScholarBank@NUS Repository.
Abstract: Cellular stressors typically induce two protective counter-responses-autophagy and the unfolded protein response (UPR). It is conceivable that these two endoplasmic reticulum (ER) membrane-based processes would intersect/interact somehow with the constitutive housekeeping process of exocytic membrane traffic from the ER. How exactly might this occur? Recent evidence indicates that a conserved Rab protein, Rab1/Ypt1p, has functional roles in UPR and autophagy. This molecular switch and its associated effectors may therefore serve to link up a network of cellular responses to stress through changes in membrane dynamics and protein turnover. The notion provides further explanations as to why elevation of Rab1/Ypt1p levels could counter the cytotoxicity of α-synuclein, and a similar mode of protection may well be at work against other stresses. © 2013 Wiley Periodicals, Inc.
Source Title: Journal of Cellular Physiology
ISSN: 00219541
DOI: 10.1002/jcp.24341
Appears in Collections:Staff Publications

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