Please use this identifier to cite or link to this item: https://doi.org/10.1017/S0007114512005491
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dc.titleIs quality of diet associated with the microvasculature? An analysis of diet quality and retinal vascular calibre in older adults
dc.contributor.authorGopinath, B.
dc.contributor.authorFlood, V.M.
dc.contributor.authorWang, J.J.
dc.contributor.authorRochtchina, E.
dc.contributor.authorWong, T.Y.
dc.contributor.authorMitchell, P.
dc.date.accessioned2014-11-25T09:46:15Z
dc.date.available2014-11-25T09:46:15Z
dc.date.issued2013-08-28
dc.identifier.citationGopinath, B., Flood, V.M., Wang, J.J., Rochtchina, E., Wong, T.Y., Mitchell, P. (2013-08-28). Is quality of diet associated with the microvasculature? An analysis of diet quality and retinal vascular calibre in older adults. British Journal of Nutrition 110 (4) : 739-746. ScholarBank@NUS Repository. https://doi.org/10.1017/S0007114512005491
dc.identifier.issn00071145
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/108443
dc.description.abstractIt is unknown whether diet quality is associated with microvascular structure. The present study aimed to investigate the relationship between diet quality, reflecting adherence to dietary guidelines, with retinal microvascular calibre in older adults. The dietary data of 2720 Blue Mountains Eye Study participants, aged 50+ years, were collected using a semi-quantitative FFQ. A modified version of the Healthy Eating Index for Australians was developed to determine total diet scores (TDS). Fundus photographs were taken and retinal vascular calibre measured using computer-assisted techniques and summarised. After adjusting for age, sex, BMI, mean arterial blood pressure, smoking, serum glucose, leucocyte count and history of diagnosed stroke or CHD, persons with higher TDS had healthier retinal vessels cross-sectionally, with wider retinal arteriolar calibre (by approximately 3 μm, comparing the highest with the lowest quartile of TDS, P trend= 0·0001) and narrower retinal venular calibre (by approximately 2·5 μm; P trend= 0·02). In younger subjects aged ≤ 65 years, increasing TDS (lowest to the highest quartile) was associated with healthier retinal vessels: approximately 4·4 μm wider retinal arteriolar (P trend< 0·0001) and approximately 2·3 μm narrower venular calibre (P trend= 0·03). After multivariable adjustment, however, baseline TDS were not associated with retinal arteriolar (P trend= 0·89) or venular calibre (P trend= 0·25), 5 years later. Also, baseline TDS were not associated with the 5-year change in retinal arteriolar (β = 0·14; P= 0·29) or venular calibre (β =-0·26; P= 0·07). Greater compliance with published dietary guidelines (higher diet quality) was cross-sectionally associated with wider retinal arterioles and narrower venules, indicating better retinal microvascular health. © 2012 The Authors.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1017/S0007114512005491
dc.sourceScopus
dc.subjectBlue Mountains Eye Study
dc.subjectDiet quality
dc.subjectOlder adults
dc.subjectRetinal vascular calibre
dc.subjectTotal diet score
dc.typeArticle
dc.contributor.departmentOPHTHALMOLOGY
dc.description.doi10.1017/S0007114512005491
dc.description.sourcetitleBritish Journal of Nutrition
dc.description.volume110
dc.description.issue4
dc.description.page739-746
dc.description.codenBJNUA
dc.identifier.isiut000322784000017
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