Please use this identifier to cite or link to this item: https://doi.org/10.2353/ajpath.2007.061149
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dc.titleInduction of apoptosis by crambene protects mice against acute pancreatitis via anti-inflammatory pathways
dc.contributor.authorCao, Y.
dc.contributor.authorAdhikari, S.
dc.contributor.authorClément, M.V.
dc.contributor.authorWallig, M.
dc.contributor.authorBhatia, M.
dc.date.accessioned2014-11-25T09:46:04Z
dc.date.available2014-11-25T09:46:04Z
dc.date.issued2007-05
dc.identifier.citationCao, Y., Adhikari, S., Clément, M.V., Wallig, M., Bhatia, M. (2007-05). Induction of apoptosis by crambene protects mice against acute pancreatitis via anti-inflammatory pathways. American Journal of Pathology 170 (5) : 1521-1534. ScholarBank@NUS Repository. https://doi.org/10.2353/ajpath.2007.061149
dc.identifier.issn00029440
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/108428
dc.description.abstractApoptosis is a teleologically beneficial form of cell death in acute pancreatitis. Our previous work has demonstrated that induction of pancreatic acinar cell apoptosis by crambene protects mice against acute pancreatitis. However, little is known about how the induction of apoptosis reduces the severity of acute pancreatitis. Because the clearance of apoptotic cells might suppress inflammation and critically regulate immune responses, we postulate that clearance of apoptotic cells stimulates an anti-inflammatory response, which has a protective action against acute pancreatitis. To test this hypothesis, induction of apoptosis in acute pancreatitis in vivo and co-cultures of peritoneal resident macrophages with apoptotic acinar cells in vitro were used as experimental systems, testing expression of phagocytic receptors and levels of inflammatory mediators. Moreover, neutralizing anti-interleukin (IL)-10 monoclonal antibody (2.5 mg/kg) was used before the induction of apoptosis in acute pancreatitis, testing whether the protection from apoptosis induction would be removed. Our study showed that clearance of apoptotic acinar cells, which may occur essentially through the CD36-positive macrophage, stimulates the release of anti-inflammatory mediators like IL-10. IL-10 plays an important role in crambene-induced protection in acute pancreatitis. Thus, induction of pancreatic acinar cell apoptosis by crambene protects mice against acute pancreatitis via induction of anti-inflammatory pathways. Copyright © American Society for Investigative Pathology.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.2353/ajpath.2007.061149
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentBIOCHEMISTRY
dc.description.doi10.2353/ajpath.2007.061149
dc.description.sourcetitleAmerican Journal of Pathology
dc.description.volume170
dc.description.issue5
dc.description.page1521-1534
dc.description.codenAJPAA
dc.identifier.isiut000246050400010
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