Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.scr.2011.01.001
Title: Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction
Authors: Timmers, L.
Lim, S.K. 
Hoefer, I.E.
Arslan, F.
Lai, R.C.
van Oorschot, A.A.M.
Goumans, M.J.
Strijder, C.
Sze, S.K.
Choo, A.
Piek, J.J.
Doevendans, P.A.
Pasterkamp, G.
de Kleijn, D.P.V.
Issue Date: May-2011
Citation: Timmers, L., Lim, S.K., Hoefer, I.E., Arslan, F., Lai, R.C., van Oorschot, A.A.M., Goumans, M.J., Strijder, C., Sze, S.K., Choo, A., Piek, J.J., Doevendans, P.A., Pasterkamp, G., de Kleijn, D.P.V. (2011-05). Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction. Stem Cell Research 6 (3) : 206-214. ScholarBank@NUS Repository. https://doi.org/10.1016/j.scr.2011.01.001
Abstract: Recent studies suggest that the therapeutic effects of stem cell transplantation following myocardial infarction (MI) are mediated by paracrine factors. One of the main goals in the treatment of ischemic heart disease is to stimulate vascular repair mechanisms. Here, we sought to explore the therapeutic angiogenic potential of mesenchymal stem cell (MSC) secretions. Human MSC secretions were collected as conditioned medium (MSC-CM) using a clinically compliant protocol. Based on proteomic and pathway analysis of MSC-CM, an in vitro assay of HUVEC spheroids was performed identifying the angiogenic properties of MSC-CM. Subsequently, pigs were subjected to surgical left circumflex coronary artery ligation and randomized to intravenous MSC-CM treatment or non-CM (NCM) treatment for 7days. Three weeks after MI, myocardial capillary density was higher in pigs treated with MSC-CM (645±114 vs 981±55 capillaries/mm2; P=0.021), which was accompanied by reduced myocardial infarct size and preserved systolic and diastolic performance. Intravenous MSC-CM treatment after myocardial infarction increases capillary density and preserves cardiac function, probably by increasing myocardial perfusion. © 2010 Elsevier B.V.
Source Title: Stem Cell Research
URI: http://scholarbank.nus.edu.sg/handle/10635/108407
ISSN: 18735061
DOI: 10.1016/j.scr.2011.01.001
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

265
checked on May 6, 2021

WEB OF SCIENCETM
Citations

258
checked on May 6, 2021

Page view(s)

85
checked on May 2, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.