Please use this identifier to cite or link to this item: https://doi.org/10.1093/hmg/ddr060
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dc.titleGenome-wide association studies in Asians confirm the involvement of ATOH7 and TGFBR3, and further identify CARD10 as a novel locus influencing optic discarea
dc.contributor.authorKhor, C.C.
dc.contributor.authorRamdas, W.D.
dc.contributor.authorVithana, E.N.
dc.contributor.authorCornes, B.K.
dc.contributor.authorSim, X.
dc.contributor.authorTay, W.-T.
dc.contributor.authorSaw, S.-M.
dc.contributor.authorLavanya, Y.Z.
dc.contributor.authorWu, R.
dc.contributor.authorWang, J.J.
dc.contributor.authorMitchell, P.
dc.contributor.authorUitterlinden, A.G.
dc.contributor.authorRivadeneira, F.
dc.contributor.authorTeo, Y.-Y.
dc.contributor.authorChia, K.-S.
dc.contributor.authorSeielstad, M.
dc.contributor.authorHibberd, M.
dc.contributor.authorVingerling, J.R.
dc.contributor.authorKlaver, C.C.
dc.contributor.authorJansonius, N.M.
dc.contributor.authorTai, E.-S.
dc.contributor.authorWong, T.-Y.
dc.contributor.authorvan Duijn, C.M.
dc.contributor.authorAung, T.
dc.date.accessioned2014-11-25T09:45:34Z
dc.date.available2014-11-25T09:45:34Z
dc.date.issued2011-05
dc.identifier.citationKhor, C.C., Ramdas, W.D., Vithana, E.N., Cornes, B.K., Sim, X., Tay, W.-T., Saw, S.-M., Lavanya, Y.Z., Wu, R., Wang, J.J., Mitchell, P., Uitterlinden, A.G., Rivadeneira, F., Teo, Y.-Y., Chia, K.-S., Seielstad, M., Hibberd, M., Vingerling, J.R., Klaver, C.C., Jansonius, N.M., Tai, E.-S., Wong, T.-Y., van Duijn, C.M., Aung, T. (2011-05). Genome-wide association studies in Asians confirm the involvement of ATOH7 and TGFBR3, and further identify CARD10 as a novel locus influencing optic discarea. Human Molecular Genetics 20 (9) : 1864-1872. ScholarBank@NUS Repository. https://doi.org/10.1093/hmg/ddr060
dc.identifier.issn09646906
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/108388
dc.description.abstractDamage to the optic nerve (e.g. from glaucoma) has an adverse and often irreversible impact on vision. Earlier studies have suggested that the size of the optic nerve head could be governed by hereditary factors. We conducted a genome-wide association study (GWAS) on 4445 Singaporean individuals (n 5 2132 of Indian and n 5 2313 of Malay ancestry, respectively), with replication in Rotterdam, the Netherlands (n 5 9326 individuals of Caucasian ancestry) using the most widely reported parameter for optic disc traits, the optic disc area. We identified a novel locus on chromosome 22q13.1, CARD10, which strongly associates with optic disc area in both Singaporean cohorts as well as in the Rotterdam Study (RS; rs9607469, perallele change in optic disc area 5 0.051 mm2; Pmeta 5 2.73310-12) and confirmed the association between CDC7/TGFBR3 (lead single nucleotide polymorphism (SNP) rs1192415, Pmeta 5 7.57310-17) and ATOH7 (lead SNP rs7916697, Pmeta 5 2.00 3 10-15) and optic disc area in Asians. This is the first Asian-based GWAS on optic disc area, identifying a novel locus for the optic disc area, but also confirming the results found in Caucasian persons suggesting that there are general genetic determinants applicable to the size of the optic disc across different ethnicities. © The Author 2011. Published by Oxford University Press. All rights reserved.
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentEPIDEMIOLOGY & PUBLIC HEALTH
dc.contributor.departmentOPHTHALMOLOGY
dc.contributor.departmentSTATISTICS & APPLIED PROBABILITY
dc.description.doi10.1093/hmg/ddr060
dc.description.sourcetitleHuman Molecular Genetics
dc.description.volume20
dc.description.issue9
dc.description.page1864-1872
dc.description.codenHMGEE
dc.identifier.isiut000289311400018
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