Please use this identifier to cite or link to this item: https://doi.org/10.1093/ndt/gfm946
Title: Genetic variation at the SLC12A3 locus is unlikely to explain risk for advanced diabetic nephropathy in Caucasians with type 2 diabetes
Authors: Ng, D.P.K. 
Nurbaya, S.
Choo, S.
Koh, D. 
Chia, K.-S. 
Krolewski, A.S.
Keywords: End-stage renal disease
Genetic susceptibility
Haplotype block
Multiple hypothesis testing
Proteinuria
Issue Date: Jul-2008
Citation: Ng, D.P.K., Nurbaya, S., Choo, S., Koh, D., Chia, K.-S., Krolewski, A.S. (2008-07). Genetic variation at the SLC12A3 locus is unlikely to explain risk for advanced diabetic nephropathy in Caucasians with type 2 diabetes. Nephrology Dialysis Transplantation 23 (7) : 2260-2264. ScholarBank@NUS Repository. https://doi.org/10.1093/ndt/gfm946
Abstract: Background. Large-scale genotyping efforts performed on Japanese subjects with type 2 diabetes have implicated polymorphisms in solute carrier family 12 (sodium/chloride transporters) member 3 (SLC12A3) as being associated with advanced diabetic nephropathy. However, it is not known whether these polymorphisms confer a risk for this complication in type 2 diabetic Caucasians. Methods. A case-control study was conducted that consisted of 295 cases with advanced diabetic nephropathy and 174 controls who have remained normoalbuminuric despite ≥7 years of diabetes. A total of 11 single nucleotide polymorphisms (SNPs) spanning the SLC12A3 locus was analysed including +34372G>A (Arg913Gln) that was the marker previously showing the strongest evidence for disease association in type 2 diabetic Japanese. Power calculations indicated that with an alpha of 0.05, our study has >90% power to detect disease associations of the magnitude previously reported for +34372G>A (Arg913Gln). Results. Allele and genotype distributions for all 11 SNPs were found to be comparable between cases and controls, consistent with the absence of disease association. This negative result was reiterated in subgroup analysis after taking into account potentially important covariates including gender, diabetes duration, blood pressure and glycaemic control. No significant disease associations were likewise found for SLC12A3 haplotypes. Allele, genotype and haplotype distributions were similar in cases regardless of whether they were proteinuric or had developed chronic renal failure/end-stage renal disease. Conclusions. Genetic variation at the SLC12A3 locus is unlikely to explain the risk for advanced diabetic nephropathy among type 2 diabetic Caucasians. © The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.
Source Title: Nephrology Dialysis Transplantation
URI: http://scholarbank.nus.edu.sg/handle/10635/108384
ISSN: 09310509
DOI: 10.1093/ndt/gfm946
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

12
checked on Dec 10, 2019

WEB OF SCIENCETM
Citations

10
checked on Dec 3, 2019

Page view(s)

56
checked on Dec 14, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.