Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pgen.1001184
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dc.titleFour novel loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation In vivo
dc.contributor.authorKamran Ikram, M.
dc.contributor.authorXueling, S.
dc.contributor.authorJensen, R.A.
dc.contributor.authorCotch, M.F.
dc.contributor.authorHewitt, A.W.
dc.contributor.authorIkram, M.A.
dc.contributor.authorWang, J.J.
dc.contributor.authorKlein, R.
dc.contributor.authorKlein, B.E.K.
dc.contributor.authorBreteler, M.M.B.
dc.contributor.authorCheung, N.
dc.contributor.authorLiew, G.
dc.contributor.authorMitchell, P.
dc.contributor.authorUitterlinden, A.G.
dc.contributor.authorRivadeneira, F.
dc.contributor.authorHofman, A.
dc.contributor.authorde Jong, P.T.V.M.
dc.contributor.authorvan Duijn, C.M.
dc.contributor.authorKao, L.
dc.contributor.authorCheng, C.-Y.
dc.contributor.authorSmith, A.V.
dc.contributor.authorGlazer, N.L.
dc.contributor.authorLumley, T.
dc.contributor.authorMcKnight, B.
dc.contributor.authorPsaty, B.M.
dc.contributor.authorJonasson, F.
dc.contributor.authorEiriksdottir, G.
dc.contributor.authorAspelund, T.
dc.contributor.authorHarris, T.B.
dc.contributor.authorLauner, L.J.
dc.contributor.authorTaylor, K.D.
dc.contributor.authorLi, X.
dc.contributor.authorIyengar, S.K.
dc.contributor.authorXi, Q.
dc.contributor.authorSivakumaran, T.A.
dc.contributor.authorMacKey, D.A.
dc.contributor.authorMacGregor, S.
dc.contributor.authorMartin, N.G.
dc.contributor.authorYoung, T.L.
dc.contributor.authorBis, J.C.
dc.contributor.authorWiggins, K.L.
dc.contributor.authorHeckbert, S.R.
dc.contributor.authorHammond, C.J.
dc.contributor.authorAndrew, T.
dc.contributor.authorFahy, S.
dc.contributor.authorAttia, J.
dc.contributor.authorHolliday, E.G.
dc.contributor.authorScott, R.J.
dc.contributor.authorIslam, F.M.A.
dc.contributor.authorRotter, J.I.
dc.contributor.authorMcAuley, A.K.
dc.contributor.authorBoerwinkle, E.
dc.contributor.authorTai, E.S.
dc.contributor.authorGudnason, V.
dc.contributor.authorSiscovick, D.S.
dc.contributor.authorVingerling, J.R.
dc.contributor.authorWong, T.Y.
dc.date.accessioned2014-11-25T09:45:20Z
dc.date.available2014-11-25T09:45:20Z
dc.date.issued2010-10
dc.identifier.citationKamran Ikram, M., Xueling, S., Jensen, R.A., Cotch, M.F., Hewitt, A.W., Ikram, M.A., Wang, J.J., Klein, R., Klein, B.E.K., Breteler, M.M.B., Cheung, N., Liew, G., Mitchell, P., Uitterlinden, A.G., Rivadeneira, F., Hofman, A., de Jong, P.T.V.M., van Duijn, C.M., Kao, L., Cheng, C.-Y., Smith, A.V., Glazer, N.L., Lumley, T., McKnight, B., Psaty, B.M., Jonasson, F., Eiriksdottir, G., Aspelund, T., Harris, T.B., Launer, L.J., Taylor, K.D., Li, X., Iyengar, S.K., Xi, Q., Sivakumaran, T.A., MacKey, D.A., MacGregor, S., Martin, N.G., Young, T.L., Bis, J.C., Wiggins, K.L., Heckbert, S.R., Hammond, C.J., Andrew, T., Fahy, S., Attia, J., Holliday, E.G., Scott, R.J., Islam, F.M.A., Rotter, J.I., McAuley, A.K., Boerwinkle, E., Tai, E.S., Gudnason, V., Siscovick, D.S., Vingerling, J.R., Wong, T.Y. (2010-10). Four novel loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation In vivo. PLoS Genetics 6 (10) : 1-12. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pgen.1001184
dc.identifier.issn15537390
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/108381
dc.description.abstractThere is increasing evidence that the microcirculation plays an important role in the pathogenesis of cardiovascular diseases. Changes in retinal vascular caliber reflect early microvascular disease and predict incident cardiovascular events. We performed a genome-wide association study to identify genetic variants associated with retinal vascular caliber. We analyzed data from four population-based discovery cohorts with 15,358 unrelated Caucasian individuals, who are members of the Cohort for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, and replicated findings in four independent Caucasian cohorts (n = 6,652). All participants had retinal photography and retinal arteriolar and venular caliber measured from computer software. In the discovery cohorts, 179 single nucleotide polymorphisms (SNP) spread across five loci were significantly associated (p
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1371/journal.pgen.1001184
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentCENTRE FOR MOLECULAR EPIDEMIOLOGY
dc.contributor.departmentOPHTHALMOLOGY
dc.description.doi10.1371/journal.pgen.1001184
dc.description.sourcetitlePLoS Genetics
dc.description.volume6
dc.description.issue10
dc.description.page1-12
dc.identifier.isiut000283647800015
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