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Title: Flicker light-induced retinal vasodilation in diabetes and diabetic retinopathy
Authors: Nguyen, T.T.
Kawasaki, R.
Jie, J.W.
Kreis, A.J.
Shaw, J.
Vilser, W.
Wong, T.Y. 
Issue Date: Nov-2009
Citation: Nguyen, T.T., Kawasaki, R., Jie, J.W., Kreis, A.J., Shaw, J., Vilser, W., Wong, T.Y. (2009-11). Flicker light-induced retinal vasodilation in diabetes and diabetic retinopathy. Diabetes Care 32 (11) : 2075-2080. ScholarBank@NUS Repository.
Abstract: OBJECTIVE - Flicker light-induced retinal vasodilation may reflect endothelial function in the retinal circulation. We investigated flicker light-induced vasodilation in individuals with diabetes and diabetic retinopathy. RESEARCH DESIGN AND METHODS - Participants consisted of 224 individuals with diabetes and 103 nondiabetic control subjects. Flicker light-induced retinal vasodilation (percentage increase over baseline diameter) was measured using the Dynamic Vessel Analyzer. Diabetic retinopathy was graded from retinal photographs. RESULTS - Mean ± SD age was 56.5 ± 11.8 years for those with diabetes and 48.0 ± 16.3 years for control subjects. Mean arteriolar and venular dilation after flicker light stimulation were reduced in participants with diabetes compared with those in control subjects (1.43 ± 2.10 vs. 3.46 ± 2.36%, P < 0.001 for arteriolar and 2.83 ± 2.10 vs. 3.98 ± 1.84%, P < 0.001 for venular dilation). After adjustment for age, sex, diabetes duration, fasting glucose, cholesterol and triglyceride levels, current smoking status, systolic blood pressure, and use of antihypertensive and lipid-lowering medications, participants with reduced flicker light-induced vasodilation were more likely to have diabetes (odds ratio 19.7 [95% CI 6.5-59.1], P < 0.001 and 8.14 [3.1-21.4], P < 0.001, comparing lowest vs. highest tertile of arteriolar and venular dilation, respectively). Diabetic participants with reduced flicker light-induced vasodilation were more likely to have diabetic retinopathy (2.2 [1.2- 4.0], P = 0.01 for arteriolar dilation and 2.5 [1.3-4.5], P = 0.004 for venular dilation). CONCLUSIONS - Reduced retinal vasodilation after flicker light stimulation is independently associated with diabetes status and, in individuals with diabetes, with diabetic retinopathy. Our findings may therefore support endothelial dysfunction as a pathophysiological mechanism underlying diabetes and its microvascular manifestations. © 2009 by the American Diabetes Association.
Source Title: Diabetes Care
ISSN: 01495992
DOI: 10.2337/dc09-0075
Appears in Collections:Staff Publications

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