Please use this identifier to cite or link to this item: https://doi.org/10.1167/iovs.09-4939
DC FieldValue
dc.titleC-reactive protein, body mass index, and diabetic retinopathy
dc.contributor.authorLim, L.S.
dc.contributor.authorShyong Tai, E.
dc.contributor.authorMitchell, P.
dc.contributor.authorWang, J.J.
dc.contributor.authorTay, W.T.
dc.contributor.authorLamoureux, E.
dc.contributor.authorWong, T.Y.
dc.date.accessioned2014-11-25T09:44:36Z
dc.date.available2014-11-25T09:44:36Z
dc.date.issued2010-09
dc.identifier.citationLim, L.S., Shyong Tai, E., Mitchell, P., Wang, J.J., Tay, W.T., Lamoureux, E., Wong, T.Y. (2010-09). C-reactive protein, body mass index, and diabetic retinopathy. Investigative Ophthalmology and Visual Science 51 (9) : 4458-4463. ScholarBank@NUS Repository. https://doi.org/10.1167/iovs.09-4939
dc.identifier.issn01460404
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/108319
dc.description.abstractPURPOSE. C-reactive protein (CRP) is an inflammatory biomarker that may be associated with diabetic retinopathy (DR), but body mass index (BMI) is an important confounder of this relationship. The purpose of this study was to determine the relationship between CRP, BMI, and existing DR. METHODS. This was a population-based, cross-sectional study on 718 persons with diabetes in the Singapore Malay Eye Study (SiMES). Diabetes was defined as random glucose ≥ 11.1 mmol/L, on diabetic medication or a history of physiciandiagnosed diabetes. CRP was measured in frozen plasma. DR was graded from retinal photographs. RESULTS. Higher CRP and BMI were associated with lower prevalence of DR. After adjustment for age, sex, HbA1c level, hypertension, smoking, total cholesterol level, cholesterol-lowering medication, and insulin use, persons with the highest quartiles of CRP were less likely to have any DR (odds ratio [OR] 0.5; 95% CI, 0.3- 0.9, comparing the fourth with the first quartile of CRP), vision-threatening DR (OR 0.3; 95% CI, 0.1- 0.7), or CSME (OR 0.2; 95% CI, 0.1- 0.6). Similarly, persons with the highest quartiles of BMI were less likely to have any DR (OR 0.5; 95% CI, 0.3- 0.7), moderate DR (OR 0.4; 95% CI, 0.2- 0.7), vision-threatening DR (OR 0.4; 95% CI, 0.1- 0.8) or CSME (OR 0.2; 95% CI, 0.0 -1.0). No significant interactions between CRP and BMI on DR were seen. CONCLUSIONS. Persons with diabetes who had higher levels of CRP and BMI were less likely to have DR. Further research is needed to understand the interrelationship role of inflammation, body weight, and microvascular complications. © Association for Research in Vision and Ophthalmology.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1167/iovs.09-4939
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentOPHTHALMOLOGY
dc.description.doi10.1167/iovs.09-4939
dc.description.sourcetitleInvestigative Ophthalmology and Visual Science
dc.description.volume51
dc.description.issue9
dc.description.page4458-4463
dc.description.codenIOVSD
dc.identifier.isiut000281502700015
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