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|Title:||Corticospinal tract degeneration in amyotrophic lateral sclerosis: A diffusion tensor imaging and fibre tractography study||Authors:||Yin, H.
|Keywords:||Amyltrophic lateral sclerosis
Echo planar imaging
Magnetic resonance imaging
|Issue Date:||May-2008||Citation:||Yin, H.,Cheng, S.H.T.,Zhang, J.,Ma, L.,Gao, Y.,Li, D.,Lim, C.C.T. (2008-05). Corticospinal tract degeneration in amyotrophic lateral sclerosis: A diffusion tensor imaging and fibre tractography study. Annals of the Academy of Medicine Singapore 37 (5) : 411-415. ScholarBank@NUS Repository.||Abstract:||Introduction: Motor neuron damage and cortical spinal tract (CST) degeneration in amyotrophic lateral sclerosis (ALS) are difficult to visualise and quantify on conventional magnetic resonance imaging (MRI). Clinical Picture: We studied 8 ALS patients and 12 normal volunteers using diffusion tensor imaging (DTI) and fibre tractography using fibre assignment by continuous tracking (FACT) to study the fibres of the CST and the posterior thalamic radiation (PTR), a non-motor tract. Outcome: Fibre tractography was successfully performed in all normal volunteers and all patients except 1. The fibre bundles of the CST, but not the PTR, were significantly reduced (P||Source Title:||Annals of the Academy of Medicine Singapore||URI:||http://scholarbank.nus.edu.sg/handle/10635/108315||ISSN:||03044602|
|Appears in Collections:||Staff Publications|
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